IMPORTANCE OF NATURAL KILLER CELLS AND TUMOR NECROSIS FACTOR IN RECURRENT PREGNANCY LOSS

IMPORTANCE OF NATURAL KILLER CELLS AND TUMOR NECROSIS FACTOR IN RECURRENT PREGNANCY LOSS

Авторы

  • KETEVAN GOTSIRIDZE
  • NIKOLOZ KINTRAIA
  • TAMAR GOGIA

DOI:

https://doi.org/10.52340/jecm.2023.05.14

Ключевые слова:

natural killer cells, tumor necrosis factor, recurrent pregnancy loss

Аннотация

            62 women with a history of habitual abortions were examined. 28 women (first A group) were terminated again in the first trimester, and 34 (first B group) continued their pregnancy. The control group consists of 40 women who did not have a history of usual abortion, 20 women of this group (the second A group) are non-pregnant and 20 (the second B) are healthy pregnant women. In both groups, women with a history of habitual abortions in the first trimester of pregnancy had increased CD16+CD56 NK cells (36.5 +/- 1.72% და 37.0 +/- 1.8% P<0.05) compared to the control group. Cytokine TNFa in the first A group was increased to 39.0 +/- 3.82 pg/ml, and in the first B group 35.1 +/- 3.3 pg/ml (p<0.05). In the first group B, only 13 pregnant women had increased TNFa (two pregnancies were terminated at 20-21 weeks), and 21 women with progressive pregnancies had decreased TNFa levels, corresponding to the acceptable norm. That is, the reduction of TNFa and the conditions of the increase of pNK cells are important for the normal course of pregnancy, and its increase can be one of the factors that negatively affects the formation of immunosuppression and provokes termination of pregnancy.

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Библиографические ссылки

Barber D.E. Faure M. Long E.O. LFA-1 contributes an early signal for NK cell cytotoxicity // J. Immuol. 2004; 173:3653-3659.

Ticconi C., Pietropolli A., Disimone N. et al. Endometrial Immun Disfunction in Recurrent Pregnancy, Loss // Inf. J Mol Sci. 2019 Nov; 20(21):5332.

Cha J, Sun X, Dey SK. Mechanisms of implantation strategies for successful pregnancy. Nat. Med. 2012; 18(12):1754-67.

Абакушина Е.В., Кузьмина Е.Г., Коваленко Е.И. – Основные свойства и функции NK клеток человека // Иммунология, 2012; 4: 220-224.

Roda Navarro P., Vales-Comez M, Chisholm S.E. et al. Transfer of NKG2D and MICB at the cytotoxic NK cell immune synapse correlates with a reduction in NK cell cytotoxic function // Ptoc. Nate. Acad Sci USA 2006; 103(30):258-263.

Shapina E., Ratzon R. et all. Primary vs. Secondary recurrent pregnancy loss epidemiological characteristics, etiology and next pregnancy outcome. J. Perinatal Med. 2012; 40(4):389.

Flether R.H. Flether S.W., Wagner E.H. Clinical Epidemiology, 1998, 33.

Chang-Ching Yen Huann-Cheng Horng, Pen-Hui Wang. Recurrent miscarriage: Are NK cell subsets a good predictor? // J. of Chin. Med. Assoc. 2019; 82:443.

Danielsson K., Medically reviewed by Brian Levine. MD. MS FACOG update on April,14.2020

Hossein S, Zarnani A.H. Asgarian-Omran H et al. Comparative analysis of NK cell subsets in menstrual and peripheral blood of patients with unexplained recurrent spontaneous abortion and fertile subjects. J. Reprod. Immunol. 2014;103:9-17.

Laird SM, Mariee N, Wei L, Li T.C Measurements of CD56+ cells in peripheral blood and endometrium by flow cytometry and immunohistochemical staining in situ Hum. Reprod. 2011 Jun; 26(6):1331-7.

Kwak-Kim J., Bao S. Lee S.K. et al Immunological models of pregnancy loss: inflammation, immune effectors and stress // Am. J. Reprod Immunol. 2014, Aug:72 (2):129-40. doi:10.1111/aji 12234

Asher Bashiri, Avi Harlev, Ashok Agarwal. Recurrent Pregnancy Loss // Springer International Publishing Switzerland, 2016, 208.

Xiaoxuan Zhao, Yuepeng Jiang, Yunlu Ping et al. Associations between tumor necrosis factor α and interleikin-6 polymorphisms and unexplained recurrent spontaneous abortion risk. A meta-analysis Medicine 2019, 98:46(e17919).

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Опубликован

2023-10-12

Как цитировать

GOTSIRIDZE, K., KINTRAIA, N., & GOGIA, T. (2023). IMPORTANCE OF NATURAL KILLER CELLS AND TUMOR NECROSIS FACTOR IN RECURRENT PREGNANCY LOSS. Experimental and Clinical Medicine Georgia, (5). https://doi.org/10.52340/jecm.2023.05.14

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