IMPORTANCE OF NATURAL KILLER CELLS AND TUMOR NECROSIS FACTOR IN RECURRENT PREGNANCY LOSS
Keywords:natural killer cells, tumor necrosis factor, recurrent pregnancy loss
62 women with a history of habitual abortions were examined. 28 women (first A group) were terminated again in the first trimester, and 34 (first B group) continued their pregnancy. The control group consists of 40 women who did not have a history of usual abortion, 20 women of this group (the second A group) are non-pregnant and 20 (the second B) are healthy pregnant women. In both groups, women with a history of habitual abortions in the first trimester of pregnancy had increased CD16+CD56 NK cells (36.5 +/- 1.72% და 37.0 +/- 1.8% P<0.05) compared to the control group. Cytokine TNFa in the first A group was increased to 39.0 +/- 3.82 pg/ml, and in the first B group 35.1 +/- 3.3 pg/ml (p<0.05). In the first group B, only 13 pregnant women had increased TNFa (two pregnancies were terminated at 20-21 weeks), and 21 women with progressive pregnancies had decreased TNFa levels, corresponding to the acceptable norm. That is, the reduction of TNFa and the conditions of the increase of pNK cells are important for the normal course of pregnancy, and its increase can be one of the factors that negatively affects the formation of immunosuppression and provokes termination of pregnancy.
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