D-DIMER AS A BIOMARKER FOR DISEASE SEVERITY IN COVID-19 PATIENTS: SOME PHYSIOLOGICAL ASPECTS
DOI:
https://doi.org/10.52340/jecm.2023.01.09Keywords:
D-dimer, COVID–19, bloodAbstract
Because of the rapid spreading and high mortality of Covid-19, it represents a global problem. According to the literature, an increase in the level of D-dimer was indicated during complications of disease and mortality. To the above-mentioned, we studied the D-dimer level in patients with Covid-19. In total, we investigated 40 Covid infected patients. As research material, we used blood. The research results showed that the level of D-dimer increases significantly in Covid-19 infected patients. And, its increasing level is associated with the severity of patients (p<0,0001). In particular, a high level of D-dimer was shown in the patients that died in the hospital. Therefore D-dimer could be used as a biomarker during Covid disease in Covid-19 patients and for prognosis and treatment management in clinical practice.
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Guan, W. J., Ni, Z. Y., Hu, Y., Liang, W. H., Ou, C. Q., He, J. X., et al. (2020). Clinical characteristics of coronavirus disease 2019 in China. New England journal of medicine, 382(18):1708-20.
Wong, J. P., Viswanathan, S., Wang, M., et al. (2017). Current and future developments in the treatment of virus-induced hypercytokinemia. Future medicinal chemistry, 9(2):169–178.
Tang, N., Bai, H., Chen, X., Gong, J., Li, D., Sun, Z. (2020). Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy. Journal of thrombosis and hemostasis: JTH, 18(5):1094–1099.
Wichmann, D., Sperhake, J. P., Lütgehetmann, M., Steurer, S., Edler, C., Heinemann, A., Kluge, S. (2020). Autopsy findings and venous thromboembolism in patients with COVID-19: a prospective cohort study. Annals of internal medicine, 173(4):268-277.
Zhang, J. J., Dong, X., Cao, Y. Y., Yuan, Y. D., Yang, Y. B., Yan, Y. Q., Gao, Y. D. (2020). Clinical characteristics of 140 patients infected with SARS‐CoV‐2 in Wuhan, China. Allergy, 75(7):1730-1741.
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