COMPARATIVE ANALYSIS OF THE SUMS OF ALKALOIDS OF SOME SPECIES OF MAHONIA (FAMILY BERBERIDACEAE), INTRODUCED ON THE TERRITORY OF GEORGIA

NIKA TODUA; DAVID CHINCHARADZE; NINA VACHNADZE

doi:10.52340/jecm.2022.03.08

COMPARATIVE ANALYSIS OF THE SUMS OF ALKALOIDS OF SOME SPECIES OF MAHONIA (FAMILY BERBERIDACEAE), INTRODUCED ON THE TERRITORY OF GEORGIA

Authors

NIKA TODUA
DAVID CHINCHARADZE
NINA VACHNADZE

DOI:

https://doi.org/10.52340/jecm.2022.03.08

Keywords:

Mahonia Nutt, isoqinolin alkaloids, сytotoxic activity

Abstract

Approaching on comparative phytochemical screening tests of six species of Genus Mahonia Nuttall (Family Berberidaceae), which are introduced on the territory of Georgia, by productivity of biologically active alkaloids our attention deserves: Mahonia aquifolium (Pursh) Nutt., Mahonia bealei (Fort.) Carr; Mahonia japonica (Thunb.) DC.; Mahonia wagneri Join.After studying samples with alkaloids on thin layer chromatography compared with standard solutions, there were identified isoquinoline alkaloids such as: berberine, jatrorrhizine, palmatine, magnoflorine, berbamine and colchicine. The total substance obtained from the vegetative organs of Mahonia aquifolium (Oregon grape) were evaluated for in vitro cytotoxicity against cells of lung carcinoma lines (A-549), colon adenocarcinoma (DLD-1) and normal human fibroblasts (WS-1). As a result, the investigated fractions showed pronounced activity against all cell lines.

Downloads

Download data is not yet available.

References

Димитриева А.А. Определитель растений Аджарии. Тбилиси, Мецниереба, 1990, 1, 328.

Пилипенко Ф.С. Иноземные деревья и кустарники на Черноморском побережье Кавказа. Л., Наука, 1978, 286.

Флора Грузии, Тбилиси, Мецниереба, 1983, 376.

Jian-Ming He, Qing Mu. The medicinal uses of the genus Mahonia in traditional Chinese medicine: An ethnopharmacological, phytochemical and pharmacological review. Journal of Ethnopharmacology, 2015, 175, 668–683.

Flora of China Editorial Committee, 2001. Flora of China. Science Press, Beijing.

Editorial Board of Zhong Hua Ben Cao, 1999. Zhong Hua Ben Cao (China Herbal). Shanghai Science and Technology Press, Shanghai.

С.А. Романадзе, М.В.Метревели. Биоэкология видов рода магония (Mahonia Nutt.) в батумском ботаническом саду. 17-ая международная конференция: Экологические проблемы XXI века. Минск, Сборник трудов конф., 2017, т. 2, 42-43.

http://www.theplantlist.org/

Ловкова М.Я. Биосинтез и метаболизм алкалоидов в растениях. Изд. Наука, М. 1981, 59-64.

Eun-Jeong Lee Peter J. Facchini. Tyrosine Aminotransferase Contributes to Benzylisoquinoline Alkaloid Biosynthesis in Opium Poppy , Plant Physiol., 2011, 157(3), 1067–1078

He, K.J., Liu, B.M., Lu, W.J., 2008. Chemical constituents from Mahonia duclouxiana Gagnep (I). West China Journal of Pharmaceutical Sciences 23, 172-173.

Hsieh, T.-J., Chia, Y.-C., Wu, Y.-C., Chen, C.-Y., Chemical constituents from the stems of Mahonia japonica. Journal-Chinese chemical society Taipei. 2004, 51, 443-446.

Ji, X.H., Pei, M.W., Tian, J.M., Yan, Y.N., Li, J.S., 2003. Study on alkaloids from stem of Mahonia eurybrateata Takeda. CHinese Traditional and Herbal Drugs 34, 980-981.

Lv, G.H., Chen, J.M., Wang, L.W., Xiao, P.G., 1995. A study on the chemical constituents of Mahonia gracilipes (oliv.) Fedde. West China Journal of Pharmaceutical Sciences 10, 202-204.

Lv, G.H., Wang, L.W., Chen, J.M., Xiao, P.G., 1999. Determination of seven alkaloids in Mahonia species by HPLC. Chinese Journal of Pharmaceutical analysis 19, 271-274.

P.Goetz, K.Ghedira. Mahonia aquifolium (Pursh.) Nutt. (Berberidaceae): Mahonia. Phytotherapie, 2014, 12, 189-193;

Dejan Godevac, Ana Damjanovic, Tatjana P.Stanojkovic, Boban Andelkovic, Gordana Zdunic. Identification of cytotoxic metabolites from Mahonia aquifolium using 1H NMR – based metabolomics approach. Journal of Pharmaceutical and Biomedical Analysis, 2018, 150, 9-14.