THE TH1/TH2 CYTOKINE PROFILE PARADIGM IN THE IMMUNOPATHOGENESIS OF PSORIASIS

Abstract

Psoriasis is a chronic inflammatory disease characterized by the presence of erythematous papules and plaques on the skin. T cell autoreactivity to a still unknown antigen plays a leading role in the pathogenesis of psoriasis. These immune cells migrate from the dermis to the epidermis and secrete chemical mediators of inflammation - proinflammatory cytokines.

The aim of our study was to study the activity of Th1/Th2 cytokine profiles in the immunopathogenesis of psoriasis. According to the obtained results, IL-2 levels are significantly increased in psoriasis patients compared to healthy and allergic groups, indicating activation of the Th1 immune line, and the low levels of IL-33 in both the psoriasis and allergy groups reflect its non-dominant role. According to the results of our study, the significantly elevated levels of IL-2 and the relatively low levels of IL-33 in patients with psoriasis indicate a shift in the Th1/Th2 immune balance towards Th1, which increases the diagnostic and immunotherapeutic value of this cytokine.