OXIDATIVE METABOLISM IN RATS WITH ACUTE HEPATIC INSUFFICIENCY

OXIDATIVE METABOLISM IN RATS WITH ACUTE HEPATIC INSUFFICIENCY

Authors

GIORGI TURKIA
NINO LOBZHANIDZE
MANANA PAPAVA
SOPHIO TURABELIDZE-ROBAKIDZE
EKA SHEKILADZE
NINO KIPIANI

DOI:

https://doi.org/10.52340/jecm.2022.06.25

Keywords:

acute hepatic insufficiency, oxidative metabolism, nitric oxide

Abstract

Liver failure is one of the most complex and unresolved problems in modern hepatology. The study aimed to study the parameters of oxidative metabolism in rats with acute hepatic insufficiency. Acute liver failure was induced by ingestion of 20% CCL4 oily solution. At the end of the experiment (3 weeks later), liver function tests (alanine aminotransferase (ALT), aspartate aminotransferase (AST), total protein, and bilirubin), antioxidant enzymes (catalase, superoxiddismutase (SOD)) nitric oxide (NO) were determined.The results of the study show that 3 weeks after the onset of CCL4-induced acute liver failure in rats, significant weight loss, liver dysfunction (increase in ALT, AST, bilirubin, total protein depletion) and oxidative stress (decreased NO content and activity of SOD and catalase).

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References

http://emedicine.medscape.com/article/177354-overview

Adewale O.B, Adekeye A.O, Akintayo C.O, Onikanni A, Sabiu Saheed Carbon tetrachloride (CCl4) induced hepatic damage in experimental S prague D awley rats: Antioxidant potential of Xylopia aethiopica. The Journal of Phytopharmacology 2014; 3(2):118-123

Basu S. Carbon Tetrachloride-Induced Hepatotoxicity: A Classic Model of Lipid Peroxidation and Oxidative Stress. In: Basu S, Wiklund L, Studies on Experimental Models. Totowa: Humana Press; 2011, 467–480.

Ichai P, Samuel D Epidemiology of liver failure. Clin Res Hepatol Gastroenterol. 2011 Oct; 35(10):610-7.

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Published

2022-06-02

How to Cite

GIORGI TURKIA, NINO LOBZHANIDZE, MANANA PAPAVA, SOPHIO TURABELIDZE-ROBAKIDZE, EKA SHEKILADZE, & NINO KIPIANI. (2022). OXIDATIVE METABOLISM IN RATS WITH ACUTE HEPATIC INSUFFICIENCY. Experimental and Clinical Medicine Georgia, (4). https://doi.org/10.52340/jecm.2022.06.25

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