ნეიტროფილურ-ლიმფოციტური ინდექსის-(NLR) კლინიკური ინდიკატორის როლი ვულგარული და პუსტულოზური ფსორიაზის დროს

NINO MELIKISHVILI; NUNU MITSKEVICHI; NINO ZHGHENTI; TAMUNA LAZASHVILI; NINO ADAMASHVILI

doi:10.52340/jecm.2026.02.12

Authors

NINO MELIKISHVILI Ivane Javakhishvili Tbilisi State University
NUNU MITSKEVICHI Ivane Javakhishvili Tbilisi State University
NINO ZHGHENTI Zurich Medical Research Centre (Tbilisi, Georgia)
TAMUNA LAZASHVILI Ivane Javakhishvili Tbilisi State University
NINO ADAMASHVILI Tbilisi State Medical University, Department of Dermatovenerology

DOI:

https://doi.org/10.52340/jecm.2026.02.12

Keywords:

Vulgar psoriasis, pustular psoriasis, NLR, Biomarker

Abstract

Psoriasis is one of the most common chronic skin diseases. The leading immunological mechanism in the pathogenesis of psoriasis is: Th1/Th2 cellular autoreactivity to a still unknown antigen.

The aim of our study was to determine the neutrophil-lymphocyte index (NLR) in the blood of patients with vulgar and pustular (rare, but more severe) psoriasis, evaluation of the potential of blood cell relative indices in clinical practice for psoriasis. NLR reflects the balance of the body's inflammatory and immune responses: neutrophils are typically associated with acute inflammation, while lymphocytes are associated with regulatory and chronic immune processes. An increase in NLR often indicates systemic inflammation, immune imbalance, or disease activity, which is why it is widely used as a prognostic or diagnostic indicator in various pathologies.

According to our results, in patients with pustular psoriasis, the neutrophil-lymphocyte index is significantly higher, reflecting an intense systemic inflammatory response and a tendency for neutrophil dominance. In the case of psoriasis vulgaris, a moderate increase in NLR corresponds to a chronic, but relatively less active inflammatory process. Accordingly, the neutrophil-lymphocyte index can be used as an additional biomarker that may reflect the form of the disease and the degree of inflammatory activity in patients with psoriasis.

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Author Biographies

NINO MELIKISHVILI, Ivane Javakhishvili Tbilisi State University

Tbilisi State University, Translational and clinical medicine

NUNU MITSKEVICHI, Ivane Javakhishvili Tbilisi State University

Tbilisi State University, Department of immunology and microbiology

TAMUNA LAZASHVILI, Ivane Javakhishvili Tbilisi State University

Tbilisi State University, Department of immunology and microbiology

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