WHEN AND FOR WHAT PURPOSES COMBINED ALLERGIC DIAGNOSTIC TESTING SHOULD BE EMPLOYED IN CHILDREN

WHEN AND FOR WHAT PURPOSES COMBINED ALLERGIC DIAGNOSTIC TESTING SHOULD BE EMPLOYED IN CHILDREN

Authors

IRINE KORINTELI Tbilisi State Medical University
IRMA KORINTELI Tbilisi State Medical University
MALVINA JAVAKHADZE Tbilisi State Medical University
LIA GELAZONIA Tbilisi State Medical University
NATO GUBELADZE Tbilisi State Medical University
NINO JANASHIA Tbilisi State Medical University
LELI SHANIDZE Tbilisi State Medical University
BAIA TSKHADASHVILI Tbilisi State Medical University

DOI:

https://doi.org/10.52340/jecm.2025.06.31

Keywords:

allergy, children, diagnosis, tests

Abstract

In pediatric practice, the issue of allergic diseases has become particularly prominent in recent years. For the purposes of prevention and treatment of these conditions, the identification of allergens is of significant importance. The aim of our study was to assess the immunological status of children with allergic diseases. Quantitative levels of IgE were measured, and a comprehensive mixed allergen panel was evaluated.

Result: An open observational study was conducted from 2022 to 2025 at the G.Zhvania University Clinic of Pediatrics, the study included 59 children aged 3 to 13 years. The highest IgE were observed in patients with recurrent bronchitis and bronchial asthma, in whom hypersensitivity to respiratory allergens was detected. In cases of allergic urticaria, where IgE levels were moderately elevated, sensitization was observed to plant pollens as well as animal dander. Patients with allergic rhinitis and conjunctivitis exhibited moderately increased IgE levels, with hypersensitivity primarily associated with seasonal allergens. Patients with normal IgE levels predominantly showed hypersensitivity to food allergens.

Conclusion: The implementation of these findings in clinical practice will enable the rational and timely diagnosis of allergic diseases. From a cost-effectiveness perspective, it is preferable to prioritize the diagnostic assessment of allergens.

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Author Biographies

IRINE KORINTELI, Tbilisi State Medical University

Tbilisi State Medical University, G. Zhvania University Clinic of Pediatrics

IRMA KORINTELI, Tbilisi State Medical University

Tbilisi State Medical University, G. Zhvania University Clinic of Pediatrics

MALVINA JAVAKHADZE, Tbilisi State Medical University

Tbilisi State Medical University, Acad. V. Bochorishvili Clinic

LIA GELAZONIA, Tbilisi State Medical University

Tbilisi State Medical University, G. Zhvania University Clinic of Pediatrics

NATO GUBELADZE, Tbilisi State Medical University

Tbilisi State Medical University, G. Zhvania University Clinic of Pediatrics

NINO JANASHIA, Tbilisi State Medical University

Tbilisi State Medical University, G. Zhvania University Clinic of Pediatrics

LELI SHANIDZE, Tbilisi State Medical University

Tbilisi State Medical University, G. Zhvania University Clinic of Pediatrics

BAIA TSKHADASHVILI, Tbilisi State Medical University

Tbilisi State Medical University, G. Zhvania University Clinic of Pediatrics

References

P. A. Eigenmann et al. Testing children for allergies: why, how, who and when. An updated statement of the European Academy of Allergy and Clinical Immunology (EAACI) Section on Pediatrics and the EAACI-Clemens von Pirquet Foundation. First published: 18 March 2013 https://doi.org/10.1111/pai.12066Citations:

https://test.ncdc.ge/pages/user/News.aspx?ID=ea1784b5-d3d0-4dd9-b29f-1369f5d6bbec

J Allergy Clin Immunol 2000;105:S547-58.

Kimishige Ishizaka, Teruko Ishizaka Identification of IgE Journal of Allergy and Clinical Immunology Volume 137, Issue 6, June 2016, Pages 1646-1650

Watanabe, D., Otawa, S., Kushima, M. et al. Association between allergen-specific immunoglobulin E sensitization, allergic rhinitis symptoms, and quality of life in school-aged children. Sci Rep 14, 31940 (2024). https://doi.org/10.1038/s41598-024-83471-8

Wen, H., Xia, H., et al. Prognostic value of serum total IgE and FeNO levels in children with atopic constitution bronchiolitis. Sci Rep 14, 21160 (2024). https://doi.org/10.1038/s41598-024-72236-y

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Published

2025-12-06

How to Cite

KORINTELI, I., KORINTELI, I., JAVAKHADZE, M., GELAZONIA, L., GUBELADZE, N., JANASHIA, N., … TSKHADASHVILI, B. (2025). WHEN AND FOR WHAT PURPOSES COMBINED ALLERGIC DIAGNOSTIC TESTING SHOULD BE EMPLOYED IN CHILDREN. Experimental and Clinical Medicine Georgia, (6), 170–173. https://doi.org/10.52340/jecm.2025.06.31

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