• IRINE KORINTELI Givi Zhvania Pediatric Academic Clinic
  • MZIA KHALVASHI “BROTHERS” International Hospital of Batumi
  • ELISO TURKADZE Tbilisi State Medical University
  • PLATON MACHAVARIANI Tbilisi State Medical University
  • KARAMAN PAGAVA Tbilisi State Medical University



covid-19, pregnancy, placenta, damage


In the current conditions of the COVID-19 pandemic, a new challenge has emerged in relation to the health of pregnant women and newborns. The aim of our work was to review the literature regarding placenta status in pregnant women infected with SARS COV2 and to compare the results of our literature analysis with relevant data from other systematic reviews on this issue. We compared the data of 5 scientific papers/results of histo-morphological research of 183 placentas. Our analysis of literature data revealed that SARS COV2 damages the placenta, and these lesions are manifested in the maternal and fetal parts of the placenta, predominantly in the form of vascular disorders. The results of our literature analysis were the same with the data of two other systematic reviews. In one of them, 1008 and in the other 1452 placenta histopathological research results were compared. Based on literature data, SARS COV2 damages the placenta, although reliable pathognomonic markers have not been rigorously identified. According to preliminary data, the presence of multiple microthrombi inside the blood vessels is noteworthy, which should be explained by the damaging effect of SARS COV2 on blood clotting factors. The deepening of scientific research on issues related to the development of microthrombus in the placenta has a principal significance. Some pathognomonic markers may be detected.


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Coronavirus disease 2019 (COVID-19) Situation Report. 22 March, 2020. World Health.Organization. source/coronaviruse/situation-reports/20200322- sitrep-62-covid-19.pdf?sfvrsn=f7764c46_2

Cherry Sun et al. The placenta in fetal growth restriction: What is going wrong? Placenta. 2020 Jul;96:10-18.

Wang Q., Zhang Y., Wu L., Niu S., Song C., Zhang Z. et al. Structural and functional basis of SARSCoV-2 entry by using human ACE2. /Cell. 2020; 181(4):894-904.

Muldoon KM, Fowler KB, Pesch MH, Schleiss MR. SARS-CoV-2: Is it the newest spark in the TORCH? /J Clin Virol. 2020 Jun;127:104372. doi: 10.1016/j.jcv.2020.104372. Epub 2020 Apr 14. PMID: 32335336

Sampling and Definitions of Placental Lesions. Amsterdam Placental Workshop Group Consensus Statement /Arch Pathol Lab Med. 2016;140:698–713; doi: 10.5858/arpa.2015-0225-CC

Elisheva D Shanes et al. Placental Pathology in COVID-19 / Am J Clin Pathol. 2020 Jun 8;154(1):23-32. doi: 10.1093/ajcp/aqaa089.

Natasha Singh, Tinera Buckley, Wendy Shertz. Placental Pathology in COVID-19: Case Series in a Community Hospital Setting /Cureus. 2021 Jan 6;13(1):e12522. doi: 10.7759/cureus.12522.

Chiara Tasca et al. Placental pathology in COVID-19 affected pregnant women: A prospective case-control study /Placenta. 2021 Jul;110:9-15. doi: 10.1016/j.placenta.2021.04.002. Epub 2021 May 5.

Rebecca et al. Placental Pathology in Covid-19 Positive Mothers: Preliminary Findings/ Pediatr Dev Pathol. 2020 May-Jun;23(3):177-180. doi: 10.1177/1093526620925569.

Sanket Jani et al. Clinical Characteristics of Mother-Infant Dyad and Placental Pathology in COVID-19 Cases in Predominantly African American Population/AJP Rep. 2021 Jan;11(1):e15-e20. doi: 10.1055/s-0040-1721673. Epub 2021 Feb 1.

Eunjin Ahn, Hyun Kang Introduction to systematic review and meta-analysis/ Korean J Anesthesiol. 2018 Apr; 71(2): 103–112. Published online 2018 Apr 2. doi: 10.4097/kjae.2018.71.2.103

Raffaella Di Girolamo et al. Placental histopathology after SARS-CoV-2 infection in pregnancy: a systematic review and meta-analysis/Am J Obstet Gynecol MFM 2021 Nov;3(6):100468. doi: 10.1016/j.ajogmf.2021.100468. Epub 2021 Aug 21.

Jan-Theile Suhren et al. Meta-analysis on COVID-19-pregnancy-related placental pathologies shows no specific pattern/Placenta. 2022 Jan;117:72-77. doi: 10.1016/j.placenta.2021.10.010. Epub 2021 Oct 19.




How to Cite

KORINTELI, I., KHALVASHI, M., TURKADZE, E., MACHAVARIANI , P., & PAGAVA, K. (2022). CAN SARS COV2 DAMAGE PLACENTA?. Experimental and Clinical Medicine Georgia, (8).




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