RESULTS OF ANOVULATION THERAPY IN WOMEN WITH POLYCYSTIC OVARY SYNDROME WITH NORMAL WEIGHT AND WITHOUT INSULIN RESISTANCE
Keywords:infertility, anovulation, polycystic ovary syndrome, inositol
In order to study the effectiveness of the treatment of anovulation with myo-inositol and d-chiro-inositol (MI:DCI) (40:1) in patients with polycystic ovary syndrome with normal body weight without insulin resistance, 88 patients with infertility were examined. Anthropometric indicators, hirsutism were measured, body mass index (BMI) was calculated, luteinizing hormone (LH), follicle-stimulating hormone (FSH), total testosterone in blood serum, glucose and insulin levels were determined, the HOMA-IR index was calculated. The therapy was carried out with myo-inositol (MI) + D-chiro-inositol (DCI). Statistical analysis was performed using software (SPSS) version 23.0. Patients were divided into 2 groups: group I - 40 women with normal BMI and HOMA-IR not exceeding 2.7, group II - 48 women with elevated and high BMI and HOMA-IR ≥2.7. The average age of patients in group I was 26.8±1.92 years, in group II - 27.0±1.56 years. Before treatment, a significant difference between the groups was observed in the BMI value (p=0.006), in the content of total testosterone, which was significantly higher in group II (p=0.053), as well as in the glucose content (p=0.024) and the HOMA-IR index (p =0.048). After 6-7 months after a 12-week course of treatment, both groups I and II showed a slight decrease in BMI. In patients of group I, the amount of LH in the blood decreased on average by 29.9% (p=0.232), in group II - by 27.0% (p=0.361). The level of FSH increased by 38.1% (p=0.052) and by 40.0% (p=0.053) in comparison with the initial level in groups I and II, respectively. The ratio of LH/FSH compared with the initial level decreased in group I by 32.3% (p=0.024), in group II by 36.6% (p=0.052). The level of total testosterone decreased in group I - by 41.8% (p=0.05), in group II - by 51.3% (p=0.011). In group I, the glucose level decreased by 10.5% (p=0.663), insulin - by 7.6% (p=0.480); in group II - by 25.8% (p=0.115) and 20.1% (p=0.042), respectively; index HOMA-IR in group I decreased by 10.0% (p=0.006), in group II - by 21.0% (p=0.394). After therapy, in the total sample, the proportion of patients with grade I hirsutism decreased from 48.9% to 9.1%; none of the women had grade II hirsutism. In women with PCOS with normal body mass index and insulin resistance, MI:DCI therapy has a positive effect on LH, FSH, LH/FSH and total testosterone ratios, and hirsutism.
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