NECROBIOSIS LIPOIDICA - CLINICAL CASE
DOI:
https://doi.org/10.52340/jecm.2025.06.25Keywords:
necrobiosis lipoidica, type 1 diabetes mellitus, clinical case, treatmentAbstract
Necrobiosis lipoidica is a rare, chronic, idiopathic granulomatous disorder of the skin, often associated with type 1 diabetes mellitus. Its exact etiology remains unknown; however, vascular disturbances involving immune complex deposition and microangiopathy are considered important contributing factors. Diagnosis is primarily clinical, although a skin biopsy may be performed to differentiate it from granuloma annulare, sarcoidosis, or necrobiotic xanthogranuloma.
Management includes topical or intralesional corticosteroids for active lesions, wound care, and surgical excision for ulcers. Ulceration and scarring are common complications, and lesions should be monitored over time. We report a clinical case that highlights the importance of clinical recognition, dermoscopy, and histopathologic confirmation of necrobiosis lipoidica in patients with diabetes mellitus, facilitating early intervention and prevention of complications.
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References
Lepe K, Riley CA, Hashmi MF, Salazar FJ. Necrobiosis Lipoidica. 2024 Jun 22. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 29083569.
Bolognia JL, Schaffer JV, Cerroni L, editors. Dermatology. 4th ed. Vol. 1. Section 8. Philadelphia: Elsevier; 2018. p. 1655–1657
Bruckner AL, Kangi S, Amagai M. Necrobiosis lipoidica. In: Kang S, Amagai M, et al. editors. Fitzpatrick’s Dermatology. 9th ed. Vol. 2. New York: McGraw-Hill; 2019. p. 2500–2501
Sibbald C, Reid S, Alavi A. Necrobiosis Lipoidica. Dermatol Clin. 2015 Jul;33(3):343-60. doi: 10.1016/j.det.2015.03.003. PMID: 26143418.
Feily A, Mehraban S. Treatment Modalities of Necrobiosis Lipoidica: A Concise Systematic Review. Dermatol Reports. 2015 Jun 8;7(2):5749. doi: 10.4081/dr.2015.5749. PMID: 26236446;
Lallas A, Apalla Z, Lazaridou E, Ioannides D. Dermatoscopy A–Z. Boca Raton (FL): CRC Press; 2020. p. 118–119. Section: Necrobiosis lipoidica.
Shrestha S, Spierings N, Marahatta S. Necrobiosis lipoidica: A case report with dermoscopic review. Clin Case Rep. 2021 Jan 3;9(3):1171-1174. doi: 10.1002/ccr3.3713. PMID: 33768804;
