THE CLINICAL AND MORPHOLOGICAL DIAGNOSIS OF A SOLID-PSEUDOPAPILLARY TUMOR OF THE PANCREAS
DOI:
https://doi.org/10.52340/jecm.2023.06.15Keywords:
pancreas, pseudopapillary tumor, diagnosisAbstract
Solid-pseudopapillary tumor or papillary cystic neoplasm of the pancreas accounts for 1-2% of non-endocrine tumors of this organ. First described in 1959, it is more common among young women. Tumor symptoms - loss of appetite, vomiting, nausea, low back pain, compression on adjacent organs are characteristic. Sometimes clinically silent tumor, can be found during clinical investigations. Macroscopically, the tumor is encapsulated, often localized in the tail and body of the pancreas. Vascularized solid-cystic structures with pseudo-papillary formations are characteristic. The histogenesis of the tumor is unknown. For 5 years out of 39 cases of pancreatic pathology, two cases (5.0%) of solid pseudopapillary tumor were revealed. Both patients were female. In both cases, a radical operation was performed. Based on histopathological and immunohistochemical studies, the solid-pseudopapillary tumors of the pancreas were established. The verification of the diagnosis needs an immunohistochemical study of biopsy and operational material.
Downloads
References
Гуревич Л.Е., Казанцева И. А. Солидно – псевдопапиллярное опухоль поджелудочной железы. Архив патологии. 2010; 72(2):52-56.
Дубова Е.А., Щеголев А.И., Мишнев О. Д., Егоров В.И. Солидно–псевдопапиллярное опухоль поджелудочной железы. Архив патологии. 2008;70(1):49-52.
Филатов А.В., Смольянникова В.А. Наблюдение солидно–псевдопапиллярной опухоли поджелудочной железы - особенности течения, сложности в диагностике, Архив патологии. 2018; 80(5):46-50.
Adams A.L, Siegal GP, Jhala NC, Solid-pseudopapillary tumor of pancreas: a review of silent clinical and pathological features Adv Anat Pathol 2008 Jan; 15(1):39-45.
Azna – Romero LJ., Grasa-Ullrich JM. // Arch.Pathol.Lab. Med. 2001; 125:1255-1256.
Bosman T, Carniero T, Hruban RH, Theise ND, eds. WHO classification of tumors of the digestive system 5th edition, Lyon: IARC; 2010.
Campbell J, Verbeke KS, Solid-pseudopapillary neoplasia. Jn: Campbell J, Verbeke KS Pathology of pancreas. A practical approach. London. Springer; 2013; 227-235.
Hamilton S.R., Altonen L.A. World Health Organization Pathology and Genetics classification of Tumors. Of Tumors of the Digestive System. Lyon, 2000.
Igbinosa O. Pseudopapillary tumor of pancreas. An algorithmic approach. JOP. 2011 May 6;12(3):262–5.
Ishikawa O., Ishiguro S., Ohhigashi H. et. al.// Gastroenterol. 1990; 85:597-601.
Kallichanda N, Tsai S. Stabile BE, Buslon V, Delgando DL, French SW. Histogenesis of solid pseudopapillary tumor of pancreas: the case for the centroclinal origin Exp. Mol. Pathol, 2006 Oct; 81 (2):101-7. Epub 2006.
Kim Y.I., Kim S.T., Lee G.K. Choi B.I. //Cancer. 1990; 65:2740-2746.
Kloppel G., Maure. R., Hofman E. et. All. // Virchowa Arch. A Patp. 179-183.
Zhou H., Cheng W., Jam K.Y. et. al. // Pediatr. Surg.int. 2001; 17:614-620.
Martin R.C.G., Klimestra D.S., Brennan M.F., Conlon K.C.// Ann. Surg. Oncol. 2002;9(1):35-40.