VITAMIN D AND THYROID HORMONES IN PATIENTS WITH BREAST BENIGN TUMOR

SALOME GLONTI; RUSUDAN VADACHKORIA; JUMBER UNGIADZE

doi:10.52340/jecm.2021.555

VITAMIN D AND THYROID HORMONES IN PATIENTS WITH BREAST BENIGN TUMOR

Authors

SALOME GLONTI
RUSUDAN VADACHKORIA
JUMBER UNGIADZE

DOI:

https://doi.org/10.52340/jecm.2021.555

Keywords:

Vitamin D, Breast Benign Tumor, BBT, Thyroid Hormones

Abstract

The Breast Benign tumor (BBT) is currently considered a significant breast health problem within women of all ages. In the present study, we aimed to investigate the Tumor markers CA125 and CA153, thyroid hormones free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), and vitamin D within benign breast tumor (BBT) during the reproduction ages. Twenty patients (ten patients in the control group and ten patients in cases (Breast Benign Tumor); Notably, the studies confirm the decrease in FT4 and FT3 and increase of the thyroid-stimulating hormone (TSH). In addition, the decreased level of Vitamin D is also revealed in BBT.

Downloads

Download data is not yet available.

References

T. Peshkova et al., “73 Study of lipid profile and thyroid hormones in patients with uterine fibroids,” in Poster, Nov. 2020, p. A41.1-A41. doi: 10.1136/ijgc-2020-IGCS.69.

I. Nakashidze et al., “138 Selected tumor markers and sex-steroid hormones in breast tumors,” in E-Poster viewings, Sep. 2019, p. A64.2-A64. doi: 10.1136/ijgc-2019-IGCS.138.

I. Nakashidze et al., “ERYTHROCYTE BLOOD GROUP ANTIGENS AND ALTERATIONS OF THE HORMONAL STATUS AMONG THE REPRODUCTIVE AGE WOMEN WITH BREAST TUMORS,” EMHPJ, vol. 7, no. 1, May 2014, doi: 10.12955/emhpj.v7i1.429.

S. Hossain, M. A. Beydoun, H. A. Beydoun, X. Chen, A. B. Zonderman, and R. J. Wood, “Vitamin D and breast cancer: A systematic review and meta-analysis of observational studies,” Clinical Nutrition ESPEN, vol. 30, pp. 170–184, Apr. 2019, doi: 10.1016/j.clnesp.2018.12.085.

M. de La Puente-Yagüe, M. A. Cuadrado-Cenzual, M. J. Ciudad-Cabañas, M. Hernández-Cabria, and L. Collado-Yurrita, “Vitamin D: And its role in breast cancer,” The Kaohsiung Journal of Medical Sciences, vol. 34, no. 8, pp. 423–427, Aug. 2018, doi: 10.1016/j.kjms.2018.03.004.

A. Angelousi et al., “Is there an association between thyroid function abnormalities and breast cancer?,” Arch. Endocrinol. Metab., vol. 61, no. 1, pp. 54–61, Feb. 2017, doi: 10.1590/2359-3997000000191.

E. Krashin, A. Piekiełko-Witkowska, M. Ellis, and O. Ashur-Fabian, “Thyroid Hormones and Cancer: A Comprehensive Review of Preclinical and Clinical Studies,” Front. Endocrinol., vol. 10, p. 59, Feb. 2019, doi: 10.3389/fendo.2019.00059.

R. Tziortzioti, “Thyroid Hormones and Vitamin D in Patients with Breast Cancer with Mutations in BRCA1 or BRCA2 Genes,” ANTICANCER RESEARCH, p. 6, 2016.

N. Ditsch et al., “Thyroid Function in Breast Cancer Patients,” ANTICANCER RESEARCH, p. 5, 2010.

D. Feldman, A. V. Krishnan, S. Swami, E. Giovannucci, and B. J. Feldman, “The role of vitamin D in reducing cancer risk and progression,” Nat Rev Cancer, vol. 14, no. 5, pp. 342–357, May 2014, doi: 10.1038/nrc3691.

J. Riedel et al., “Vitamin D and Mammographic Findings,” Geburtshilfe Frauenheilkd, vol. 76, no. 05, pp. 570–578, May 2016, doi: 10.1055/s-0042-106208.

C. J. Narvaez and J. Welsh, “Role of Mitochondria and Caspases in Vitamin D-mediated Apoptosis of MCF-7 Breast Cancer Cells,” Journal of Biological Chemistry, vol. 276, no. 12, pp. 9101–9107, Mar. 2001, doi: 10.1074/jbc.M006876200.

D. D. Bikle, “Vitamin D: Newer Concepts of Its Metabolism and Function at the Basic and Clinical Level,” Journal of the Endocrine Society, vol. 4, no. 2, p. bvz038, Feb. 2020, doi: 10.1210/jendso/bvz038.

H. F. DeLuca, “Overview of general physiologic features and functions of vitamin D,” The American Journal of Clinical Nutrition, vol. 80, no. 6, pp. 1689S-1696S, Dec. 2004, doi: 10.1093/ajcn/80.6.1689S.

C. J. Narvaez, D. Matthews, E. LaPorta, K. M. Simmons, S. Beaudin, and J. Welsh, “The impact of vitamin D in breast cancer: genomics, pathways, metabolism,” Front. Physiol., vol. 5, Jun. 2014, doi: 10.3389/fphys.2014.00213.

C. F. Garland et al., “The Role of Vitamin D in Cancer Prevention,” Am J Public Health, vol. 96, no. 2, pp. 252–261, Feb. 2006, doi: 10.2105/AJPH.2004.045260.