INFLUENCE OF SACUBITRIL/VALSARTAN COMBINATION ON CARDIAC HISTOMORPHOLOGICAL AND MORPHOMETRIC CHANGES
DOI:
https://doi.org/10.52340/jecm.2023.06.08Keywords:
sacubitril, valsartan, combination, cardiac, histomorphological, morphometricAbstract
Arterial hypertension is one of the most common disease worldwide, which remains the main risk factor for complications of cardiovascular diseases. As it is already known, arterial hypertension affects many organs and organ systems, including the cardiovascular system. Therefore, it is important to start treatment at an early stage of its development and remove the influence on heart remodeling. The study was carried out on 40 male Wistar rats weighing 250.0-300.0g. Animals were randomly divided into the following groups: I – control group (n=10); II – experimental, DOCA (deoxycorticosterone acetate) saline group, for 28 days, to create arterial hypertension, 25 mg/kg DOCA was injected intraperitoneally and animals were given only saline solution (1% NaCl and 0.2% KCl) to drink (n=10); III – treated group. After the development of arterial hypertension (25 mg/kg DOCA and drinking saline solution (1% NaCl and 0.2% KCl)), 30 mg/kg sacubitril-valsartan combination was administered by intraperitoneal injection for 2 weeks (n=10); IV – preventive group. intraperitoneally 25 mg/kg DOCA + 1% NaCl and 0.2% KCl in drinking water + 30 mg/kg sacubitril-valsartan combination for 2 weeks, (n=10); As a result of the study, in the control group, focal moderate blood flow and transverse arrangement of cardiomyocytes were revealed, associated with hypertrophy of cardiomyocytes in the anterior wall of the ventricle in hypertension and fibrosis of the perivascular space compared to the control; Preservation of striations in the post-treatment period, with loss of architecture of fiber structures and wavy structure. In the case of prevention, compared to the control and hypertension groups, the preservation of striation was predominantly manifested. Based on the obtained results, the sacubitril-valsartan combination inhibits the development of cardiac remodeling during its preventive use in the process of formation of arterial hypertension.
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