THE DIAGNOSTIC POTENTIAL OF URINAY AND SERUM CYTOKERATINS FOR URINARY BLADDER CANCER
DOI:
https://doi.org/10.52340/jecm.2021.562Keywords:
cancer, urinary bladder, tumor marker UBC (Urinary bladder cancer), TPAAbstract
In our opinion, the obtained results show that the level of UBC cytokeratin determined in urine reflects the destruction of tissue by the tumor to a greater extent with deep invasion and with large tumor sizes. We believe that a decrease in the sensitivity of the UBC test in detecting recurrence in patients after TUR, in comparison with the sensitivity of the UBC test in patients with BC prior to treatment, is associated with an initial level of cytodestruction in the relapse of BC. The level of serum cytokeratin TPA largely reflects the onset of metabolic changes in the tumor focus. It is the combination of UBC + TPA tests that gives rise to true-positive results and a reduction in false-negative results, which increases the sensitivity of the method.
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Злокачественные новообразования в России в 2017 году (заболеваемость и смертность). Под редакцией А.Д. Каприна, В.В. Старинского, Г.В. Петровой.
J. Ferlay, P. Autier, M. Boniol, M. Heanue, M. Colombet, P. Boyle. estimates of the cancer incidence and mortality in Europe in 2006, annals of oncology, volume 18, issue 3, march 2007, 581-592
Chou, R., & Dana, T. (2010). Screening adults for bladder cancer: A review of the evidence for the U.S. Preventive Services Task Force. Annals of internal medicine, 153 (7), 461-468.
С.Х. Аль-Шукри, И.А. Корнеев, 2003, общие принципы лечения больных раком мочевого пузыря. (Московское Онкологическое общество).
Margaret A. Knowles , Molecular subtypes of bladder cancer: Vol. 27, Issue 3, March 2006, 361–373.
Измайлов А.А., Викторова Т.В., Урманцев М.ФАполихин О.И., маркеры прогноза лимфогенного метастазирования рака мочевого пузыря, Башкирский государственный медицинский университет, г. Уфа.
M. Zargar, M. Soleimani, M. Moslemi, Comparative Evaluation of Urinary Bladder Cancer Antigen and Urine Cytology in the Diagnosis of Bladder Cancer, Urology Journal, Vol. 2, 3 (2005), 28 April 2009, 137-140.
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