THE EFFECTS OF DIAGNOSTIC ULTRASOUND ON WISTAR RATS DURING PREGNANCY AND THE BEHAVIOR OF THEIR OFFSPRING IN THE OPEN FIELD

THE EFFECTS OF DIAGNOSTIC ULTRASOUND ON WISTAR RATS DURING PREGNANCY AND THE BEHAVIOR OF THEIR OFFSPRING IN THE OPEN FIELD

Authors

  • ALEXANDER TARKHNISHVILI
  • MARINA NIKOLAISHVILI

DOI:

https://doi.org/10.52340/jecm.2022.08.21

Keywords:

diagnostic ultrasound, wistar rats, pregnancy, behavior, offspring

Abstract

The data obtained indicate that the impact of ultrasound on rats during their stay in the womb causes the development of anxiety and depression, which is clearly seen as a result of our observations. The decrease in anxiety is due not only to residual effects of organic changes in brain structures associated with the organization of behavior, in particular, specific glutamatergic neurons, the "attack center" of the hypothalamus, but also to the activation of the entire adaptive-compensatory system, which is carried out as a result of prolonged ultrasonic exposure. It is seen from the behavioral components we conducted, namely, from the results obtained in the "open field". The clarification of these issues will deepen the current understanding of the effects of prolonged 20-30 min ultrasound exposure in rats in utero, and future studies of animal nervous system dysfunction.

Downloads

Download data is not yet available.

References

Autism and Developmental Disabilities Monitoring Network Surveillance Year 2008 Principal Investigators; Centers for Disease Control and Prevention. Prevalence of autism spectrum disorders--Autism and Developmental Disabilities Monitoring Network, 14 sites, United States 2008. MMWR Surveillance Summaries. 2012; 61(3):1–19.

Grether JK, Li SX, Yoshida CK, Croen LA. Antenatal ultrasound and risk of autism spectrum disorders. Journal of Autism and Developmental Disorders. 2010; 40(2):238–45.

Lyall K, Pauls DL, Spiegelman D, Ascherio A, Santangelo SL. Pregnancy complications and obstetric suboptimality in association with autism spectrum disorders in children of the Nurses’ Health Study II. Autism Research. 2012; 5(1):21–30.

Lin CS, Tao PL, Jong YJ, Chen WF, Yang CH, Huang LT, Chao CF, Yang SN. Prenatal morphine alters the synaptic complex of postsynaptic density 95 with N-methyl-D-aspartate receptor subunit in hippocampal CA1 subregion of rat offspring leading to long-term cognitive deficits. Neuroscience. 2009 Feb 18;158(4): 1326-37.

Moy SS, Nadler JJ, Young NB, Perez A, Holloway LP, Barbaro RP, et al. Mouse behavioral tasks relevant to autism: Phenotypes of 10 inbred strains. Behavioral Brain Research. 2007; 176:4–2.

Miller DL. Safety assurance in obstetrical ultrasound. Semin Ultrasound CT MR 2008; 29:156–164.

Miller MW, Nyborg WL, Dewey WC, Edwards MJ, Abramowicz JS, Brayman AA. Hyperthermic teratogenicity, thermal dose and diagnostic ultrasound during pregnancy: implications of new standards on tissue heating. Int J Hyperthermia. 2002;18:361–384.

Maeda K, Ohkura S, Tsukamura H. Physiology and reproduction, In: Krinke GJ. The laboratory rat London (UK): Academic Press. 2000; 145–176.

Stalberg K, Axelsson O, Haglund B, Hultman CM, Lambe M, Kieler H. Prenatal ultrasound exposure and children’s school performance at age 15-16: follow-up of a randomized controlled trial. Ultrasound in Obstetrics and Gynecology. 2009; 34(3):297–303.

Sikov, M.R., B.P. Hildebrand, and J.D. Stearns. Postnatal sequelae of ultrasound exposure at 15 days of gestation in the rat. In: Ultrasound in Medicine. D. White and R.E. Brown, eds. Plenum Press, NY, 1977; 2017-23.

Spurney CF, Leatherbury L, Lo CW. High-frequency ultrasound database profiling growth, development, and cardiovascular function in C57BL/6J mouse fetuses. J Am Soc Echocardiogr. 2004;17:893–900.

Tarantal AF, O'Brien WD, Hendrickx AG. Evaluation of the bioeffects of prenatal ultrasound exposure in the cynomolgus macaque (Macaca fascicularis): III. Developmental and hematologic studies. Teratology. 1993 Feb;47(2):159-70. doi: 10.1002/tera.1420470208. PMID: 8446929.

Vorhees, CV. Principles of Behavioral Teratology. In: Riley, RP.; Vorhees, CV., editors. Handbook of Behavioral Teratology. New York: Plenum Press; 1986; 23-48.

Williams EL, Casanova MF. Reassessment of teratogenic risk from antenatal ultrasound. Translation Neuroscience. 2013; 4(1):81–87.

Verlohren S, Niehoff M, Hering L, Geusens N, Herse F, Tintu AN, Plagemann A, LeNoble F, Pijnenborg R, Muller DN, Luft FC, Dudenhausen JW, Gollasch M, Dechend R. Uterine vascular function in a transgenic preeclampsia rat model. Hypertension. 2008; 51:547–553

Warkany J. Teratogen update: hyperthermia. Teratology. 1986; 33:365–371.

Weiss J, Taylor GR, Zimmermann F, Nebendahl K. Collection of body fluids, In: Krinke GJ. The laboratory rat London (UK): Academic Press. 2000; 485–510.

Zagzebski, J.A. Acoustic output of ultrasound equipment: Summary of data reported to the A41UM Ultrasound Med. Biol., 1989; 15(l):55.

Yu Q, Leatherbury L, Tian X, Lo CW. Cardiovascular assessment of fetal mice by in utero echocardiography. Ultrasound Med Biol. 2008; 34:741–752.

Zhou YQ, Foster FS, Qu DW, Zhang M, Harasiewicz KA, Adamson SL. Applications for multifrequency ultrasound biomicroscopy in mice from implantation to adulthood. Physiol Genomics. 2002;10:113–126.

Downloads

Published

2022-12-07

How to Cite

TARKHNISHVILI, A., & NIKOLAISHVILI, M. (2022). THE EFFECTS OF DIAGNOSTIC ULTRASOUND ON WISTAR RATS DURING PREGNANCY AND THE BEHAVIOR OF THEIR OFFSPRING IN THE OPEN FIELD. Experimental and Clinical Medicine Georgia, (8). https://doi.org/10.52340/jecm.2022.08.21

Issue

Section

Articles

Most read articles by the same author(s)

Similar Articles

<< < 3 4 5 6 7 8 9 10 11 > >> 

You may also start an advanced similarity search for this article.

Loading...