PROGNOSTIC SIGNIFICANCE OF IL-6 IN STILLBIRTH DURING COVID 19 PANDEMIC
Keywords:Prognostic significance, IL-6, Stillbirth, COVID 19
The pro inflammatory cytokine IL-6 was studied by the method of immune-ferment analysis (IFA) in the blood serum in women with stillbirth during COVID infection. 3 patients suffering from this complication were examined (the principal group) and 25 patients - of adequate age groups and gestation periods but live fetuses in both groups presented SARS COV 2 infection which was confirmed with laboratory PCR (Polymerase Chain Reaction) test. The result of studies showed that the content of proinflammatory cytokine IL-6 in women with antenatal fetal death was significantly higher in the blood than in patients with normal progress of pregnancy. The obtained data prove that further studies of cytokine profile and especially of IL-6 may become an important method for the prognosis for stillbirth during SARS COV 2 pandemic period.
Critical Care Obstetrics and Gynecology, ISSN 2471-9803.
Mor G, Aldo P, Alvero AB. The unique immunological and microbial aspects of pregnancy. Nat Rev Immunol. 2017 Aug; 17(8):469-482.
Wong SF, Chow KM. Pregnancy and Perinatal Outcomes of women with severe acute respiratory syndrome. Am J Obstet Gynecol 2004 Jul; 191(1):292-297.
Fried M, Kurtis JD et al. Systemic inflammatory response to Malaria during pregnancy is associated with pregnancy loss and preterm delivery. Clin Infect Dis. 2017 Oct 30; 65(10):1729-1735.
Yokie LJ, Iwasaki. A. Interferons and proinflammatory cytokines in pregnancy and fetal development. Immunity. 2018 Sep 18; 49(3):397-412.
Liu Y, Chen H. et al. Withdrawn: Clinical manifestation and outcome of SARS -CoV-2 Infection during pregnancy. J Infect. 2020 Mar 5; S0163-4453(20)30109-2.
Hirshberg A, Kern-Goldberger AR, Levine LD et al. Care of critically ill pregnant patients with coronavirus disease 2019: a case series. Am J Obstet Gynecol. 2020 Aug; 223(2):286-290.
WHO coronavirus Disease Pandemic 2021
Napoli C, Benincasa G. et al. Immune reactivity during covid-19 implications for treatment. Immunol Lett. 2021 Mar; 231:28-34.