GHRELIN LEVEL CHANGES IN HUMANS WITH TYPE 2 DIABETES MELLITUS  AND OBESITY

NATIA  CHKHEIDZE; NIKO  URIDIA; ELENE  GIORGADZE; MARINA  NIKOLAISHVILI; ANA  MALAZONIA; TAMAR  ZEREKIDZE

doi:10.52340/jecm.2022.06.012

GHRELIN LEVEL CHANGES IN HUMANS WITH TYPE 2 DIABETES MELLITUS AND OBESITY

Authors

NATIA CHKHEIDZE
NIKO URIDIA
ELENE GIORGADZE
MARINA NIKOLAISHVILI
ANA MALAZONIA
TAMAR ZEREKIDZE

DOI:

https://doi.org/10.52340/jecm.2022.06.012

Abstract

Purpose: The aim of the research was to identify the plasma ghrelin concentration in humans with Type 2 Diabetes mellitus and obesity and to investigate a statistically significant relation between plasma ghrelin levels and other important metabolic factors in Type 2 Diabetes mellitus and obesity pathogenesis.

Downloads

Download data is not yet available.

References

Date Y, Ghrelin and the vagus nerve, Methods Enzymol, 2012;514:261–9.

Coiro V, Volpi R, Stella A et al., Oxytocin does not modify GH, ACTH, cortisol and prolactin responses to Ghrelin in normal men, Neuropeptides, 2011;45:139–42.

Castañeda TR, Tong J, Datta R, et al., Ghrelin in the regulation of body weight and metabolism, Front Neuroendocrinol, 2010;31:44–60.

Sun Y, Wang P, Zheng H, Smith RG, Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor, Proc Natl Acad Sci USA, 2004;101:4679–84.

Cowley MA, Smith RG, Diano S, et al., The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis, Neuron, 2003;37:649–61.

Chuang JC, Sakata I, Kohno D, Perello M, Osborne-Lawrence S, Repa JJ, Zigman JM. Ghrelin directly stimulates glucagon secretion from pancreatic a-cells. Mol Endocrinol. 2011;25(9):1600–1611.

Tong J, Prigeon RL, Davis HW, Bidlingmaier M, Kahn SE, Cummings DE, Tschöp MH, D’Alessio D. Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans. Diabetes. 2010;59(9):2145–2151.

Page LC, Gastaldelli A, Gray SM, D’Alessio DA, Tong J. Interaction of GLP-1 and Ghrelin on Glucose Tolerance in Healthy Humans. Diabetes. 2018;67(10):1976–1985.

Dezaki K, Hosoda H, Kakei M, Hashiguchi S, Watanabe M, Kangawa K, Yada T. Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca21signaling in b-cells: implication in the glycemic control in rodents. Diabetes. 2004; 53(12):3142–3151.

Müller TD, Nogueiras R, Andermann ML, Andrews ZB, Anker SD, Argente J, Batterham RL, Benoit SC, Bowers CY, Broglio F, Casanueva FF, D’Alessio D, Depoortere I, Geliebter A, Ghigo E, Cole PA, Cowley M, Cummings DE, Dagher A, Diano S, Dickson SL, Dieguez C, Granata R, Grill HJ, Grove K, Habegger KM, Heppner K, Heiman ML, Holsen L, Holst B, Inui A, Jansson JO, Kirchner H, Korbonits M, Laferre`re B, LeRoux CW, Lopez M, Morin S, Nakazato M, Nass R, Perez-Tilve D, Pfluger PT, Schwartz TW, Seeley RJ, Sleeman M, Sun Y, Sussel L, Tong J, Thorner MO, van der Lely AJ, van der Ploeg LH, Zigman JM, Kojima M, Kangawa K, Smith RG, Horvath T, Tschöp MH. Ghrelin. Mol Metab. 2015 Mar;4(6):437–460.

Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes. 2001;50(8): 1714–1719.

Tschöp M, Wawarta R, Riepl RL, Friedrich S, Bidlingmaier M, Landgraf R, Folwaczny C. Post-prandial decrease of circulating human ghrelin levels. J Endocrinol Invest. 2001;24(6): RC19–RC21.

Iwakura H, Kangawa K, Nakao K. The regulation of circulating ghrelin—with recent updates from cell-based assays. Endocr J. 2015;62(2):107–122.

Mani BK, Uchida A, Lee Y, Osborne-Lawrence S, Charron MJ, Unger RH, Berglund ED, Zigman JM. Hypoglycemic effect of combined ghrelin and glucagon receptor blockade. Diabetes. 2017;66(7):1847–57

McCowen KC, Maykel JA, Bistrian BR, Ling PR. Circulating ghrelin concentrations are lowered by intravenous glucose or hyperinsulinemic euglycemic conditions in rodents. J Endocr.2002;175(2):R7–R11

Briatore L, Andraghetti G, Cordera R. Acute plasma glucose increase, but not early insulin response, regulates plasma ghrelin. Eur J Endocrinol. 2003;149(5):403–406.

Lauritzen ES, Voss T, Kampmann U, Mengel A, Vendelbo MH, Jørgensen JO, Møller N, Vestergaard ET. Circulating acylghrelin levels are suppressed by insulin and increase in response to hypoglycemia in healthy adult volunteers. Eur J Endocrinol. 2015; 172(4):357–362.

Gagnon J, Anini Y. Insulin and norepinephrine regulate ghrelin secretion from a rat primary stomach cell culture. Endocrinology. 2012;153(8):3646–3656.

Sakata I, Park WM, Walker AK, Piper PK, Chuang JC, Osborne-Lawrence S, Zigman JM. Glucose-mediated control of ghrelin release from primary cultures of gastric mucosal cells. Am J Physiol Endocrinol Metab. 2012;302(10):E1300–E1310.

Gagnon J, Baggio LL, Drucker DJ, Brubaker PL. Ghrelin is a novel regulator of GLP-1 secretion. Diabetes. 2015;64(5):1513–1521.

Theander-Carrillo C, Wiedmer P, Cettour-Rose P, et al., Ghrelin action in the brain controls adipocyte metabolism, J Clin Invest, 2006;116:1983–93.

Davies JS, Kotokorpi P, Eccles SR, et al., Ghrelin induces abdominal obesity via GHS-R-dependent lipid retention, Mol Endocrinol, 2009;23:914–24.

Perez-Tilve D, Heppner K, Kirchner H, et al., Ghrelin-induced adiposity is independent of orexigenic effects, FASEB J, 2011;25:2814–22.

Li Z, Xu G, Qin Y, et al., Ghrelin promotes hepatic lipogenesis by activation of mTOR-PPARγ signaling pathway, Proc Natl Acad Sci U S A, 2014;111:13163–8