ALTERATIONS OF THE OSTEOINTEGRATION MARKERS AFTER DENTAL IMPLANTATION

Abstract

The stability of the implant depends significantly on the process of osseointegration between the bone and the implant. The cellular and molecular mechanisms of the osseointegration process have not yet been fully established and require further research in this direction.The aim of the study was to study the markers of the processes of osteointegration after dental implantation. The study was conducted on 31 patients who underwent implantation at the base of "Unident" and "A1" clinics.We collected gingival crevicular fluid (GCF) and peri-implant sulcus fluid (PISF) from patients before implantation and 1 month after implantation. In PISF and GCF fluids, bone markers (osteoprotegerin (OPG), osteocalcin (OC), osteopontin (OPN), bone-specific alkaline phosphatase (bALP)) were determined by the immunoenzymatic method.The PISF and GCF were collected using standardized paper strips (Periopaper, no.593525), which were placed at the entrance of the grooves of the implant and/or healthy teeth at a standardized depth of 1 mm for 30 seconds. The content of the OPG, OC and bALP in the PISF fluid 1 month after implantation does not change statistically significantly compared to the initial values in the GCF fluid (p=0.74; p=0.44; p=0.69). 1 month after the implantation, the content of OPN in PISF fluid increased by 133% compared to its content in GCF fluid before implantation (p<0.001).According to the study results, the OPN content in the PISF fluid increases sharply 1 month after the implantation. This parameter can be used as a marker of implant integration with living bone and bone wound healing.