SPECTRUM OF ERYTHROCYTE MEMBRANE PROTEIN ABSORPTION IN THE VILLAGES OF SACHKHERE DISTRICT
Keywords:erythrocytes membrane, UV absorption spectra, protein folding
The presented results introduce the absorption intensity of the erythrocytes' membrane proteins of the practically healthy inhabitants of the ethnic homogeneous population of the Sachere region (Georgia).Blood of the practically healthy inhabitants of the villages of the Sachere region - Sareki, Sairhe, and Chorvila, was investigated.The absorption at 230 nm in the erythrocytes' membrane proteins of the inhabitants from Sairhe did not differ from that of the level of the absorption in inhabitants from Chorvilla but was 14% higher in residents from Sareki. It is known that the absorbance at 230 nm is related to the peptide and SS-bonds in the proteins, and its lowering during unfolding proteins and change in their conformation; this can be related to an imbalance of the redox system earlier detected by us in the residents of Sareki in Sairhe.We propose that the intensity of absorption of the erythrocytes' membrane proteins at 230 nm can be considered a risk factor for the development of various chronic diseases, including cancer, associated with oxidative stress.
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