FORMULATION AND TECHNOLOGY OF OROMUCOADHESIVE PLATES OF COMPLEX COMPOSITION

Abstract

One of the most frequent diseases is inflammation in the oral cavity. Among them, stomatitis is the leading cause of inflammation of the mucous membranes. The most efficient form of treatment in this process is local and systemic forms. Oral films are perceived as the most effective and rational forms, it adheres to the mucous membrane, which ensures a much higher pharmacological effect.

Based on theoretical and experimental studies, rosehip oral mucoadhesive films (rosehip oil-2g, acyclovir-1g, sodium KMC-2g, sodium alginate-2,0, glycerin-3g, aqueous chamomile extract-up to 100g) and the technology were developed, which has prolonged, antiseptic, antiviral, and anti-inflammatory effects. Additionally, its standardization indicators were also studied: organoleptic characteristics - a film color is yellow, it is homogeneous and does not contain mechanical inclusions and air bubbles; Dimensions - 1±0.021cm ×1cm±0.1cm ×0.146±0.01; pH: 7.2; Adhesion test: the film sticks to the finger when pressed with a (wet) thumb; Bendability test - satisfactory (folding 50 times); Air permeability - 98.987g/m2h; loss in mass - 8.5%; moisture absorption rate-8%; Strength - 28.1±1.26 N/m2 ×105. The release of the substance is determined using Franz diffusion cells. Quantification of the active substance-acyclovir was done by spectrophotometric method at 255 nm wavelength, full release time – 110mn