DETERMINATION OF IN VITRO OUTLET OF LIZINOPRIL CONTAINING MEDICAL PREPARATION ”LIZINOCOR” AND ITS ANALOGUE USING METHOD OF HIGHPERFORMANCE LIQUID CHROMATOGRAPHY

Abstract

ACE Inhibitors represent the first class of anti hypertensive agents that was designed and developed on the basis of a  well-defined physiopathol ogical axis of arterial hypertension, a vascular disorder that is now becoming one of the major causes of morbidity/mortality, not only in developed societies but also in the highly populated developing countries. An angiotensin-converting enzyme (ACE) inhibitor, the  carboxylalkyl compounds derivated  lizinopril  is apharmaceutical  drug,    used primarily for the treatment of hypertension  (elevated blood pressure) and congestive heart failure. Purpose of investigation was – comparison of in vitro outlet of 5 mg tablets of  ”Lizinocor” containing Lizinopril , produced by the Georgian pharmaceutical company “GMP” and its analogue ”Zestril” using method of high-performance liquid chromatography. According to the received results average percent quantity  outlet of ”lizinocor” is 97,65 %, ”Zestril” – 95, 88%;. Inclination in comparison with Zestril is 1,85 %, (norm ± 5 %). ”Lizinocor” 5 mg tablets containing Lizinopril produced by the Georgian pharmaceutical company ”GMP” are characterized by good outlet quality.