”AMRADIPIN” 4/5 MG TABLETES USING METHOD OF HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY

Abstract

 Cardiovascular disease is one of the most serious problems in the modern world. In developed countries and among them, in Georgia, these diseases are considered a major cause of loss of human ability and mortality. Adequate control of arterial hypertension reduces the development of brain stroke and cardiovascular disease and the risk of death due to these 117 diseases. According to numerous data, 70% of people with arterial hypertension require combined treatment. One of the most successful combination is a combination of angiotensin-converting enzyme inhibitor - Perindopril and calcium antagonist – Amlodipine.   Purpose of investigation was – determination of in vitro outlet of amlodipine and perindopril in ”amradipin” 4/5 mg tablets produced by the Georgian pharmaceutical company “GMP.”  According to the received results average percent quantity outlet of amlodipine besylate is 93,81 %, average percent quantity outlet of perindopril erbumine -– 93, 91%;. (norm- not less 80 %). ”amradipin” 4/5 mg tablets containing amlodipine besylate and perindopril erbumine, produced by the Georgian pharmaceutical company ”GMP” are characterized by good outlet quality.