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Abstract
Influence of the halothane on behavioral parametrs and adaptation ability of experimental animals has been studied. The high level research activity has been determined in all three groups in the first three days of experiment. The adaptation to environment has been revealed in control group after 2 days from sham operation and halothane anesthesia while the high level of research activity has been maintained in the test group. The adaptation and decreasing of fear has been detected in the control group on the 5th day of experiment. The high level research activity in the test group indicates to difficulties in adaptation and space orientation. It is established that decreasing of adaptation ability and difficulties in space orientation in rat are stipulated by suppression of inhibitory neurotransmission in hippocampal CA3 filed. The Modulating influence of midazolam on secretion of GABA from these cells has also been shown.
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