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Abstract
Nowadays, cosmetic products containing natural ingredients are of particular interest in terms of skin care due to their protective and wide spectrum of action. The dry extract obtained from grapefruit seeds, is rich in flavonoids and has an antioxidant effect, it is also characterized as an anti-inflammatory, anti-hyperlipidemic agent. Currently, among the cosmetics used for facial skin care, microsponges and lotions containing them are preferred.
The objective of present study was to formulate and evaluate of lotion containing grapefruit microsponges. Based on the biopharmaceutical studies, optimal formulations of grapefruit microsponges and its containing lotion have been determined, also preparation technologies have been developed. The prepared lotions were oil in water (O/W) type emulsion.
By the evaluation results of homogeneity, pH, colloidal stability, accelerated stability test, spreadability and viscosity - grapefruit lotion meets the requirements of the State Pharmacopoeia for soft dosage forms;
The diffusion profile of API from grapefruit lotion was studied in an in vitro assay using Franz diffusion cells. It is established that during the entire period of exposure (180 min) the penetration of naringenin increases evenly and reaches 50%.
The stability of product has been studied and it meets appropriate standards while stored in normal conditions and maintains optimal quality characteristics throughout the observation period - one year.