Cytotoxic activity of the biological active compounds from the buds of Populus tremula L. growing in Georgia

Authors

  • Kvaratshkelia T.
  • Jokhadze M.
  • Mshvildadze V.
  • Legault J.
  • Kuchukhidze J.

Keywords:

Cytotoxic, tremula L

Abstract

Populus tremula L. (Salicaceae) is a tree growing in the deciduous forests of Georgia. The aim of the study was the simultaneous determination of compounds extracted by solvents of different polarities from buds of Populus tremula and their in vitro cytotoxic activity. The components containing in Hexane extract consists of aromatic compounds, sesquiterpene hydrocarbons and sesquiterpenoids. The components containing ethyl acetate extract consist of polyols. The main fraction of the ethylacetate extract consists of acidic compounds of aliphatic and aromatic series. The former is represented by saturated and unsaturated mono-, dicarboxylic and hydroxycarboxylic acids. Cytotoxic studies show, that the Hexane and Ethyl acetate extracts of the buds of P. tremula grown in Georgia have specific cytotoxic activity in cancer cells: A-549 (lung carcinoma), DLD-1 (intestinal adenocarcinoma), WS-1 (human fibroblasts).

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Published

2021-07-21

How to Cite

Kvaratshkelia T., Jokhadze M., Mshvildadze V., Legault J., & Kuchukhidze J. (2021). Cytotoxic activity of the biological active compounds from the buds of Populus tremula L. growing in Georgia. TSMU COLLECTION OF SCIENTIFIC WORKS, 54. Retrieved from https://journals.4science.ge/index.php/CSW/article/view/424