Keywords
tremula L
How to Cite
Abstract
Populus tremula L. (Salicaceae) is a tree growing in the deciduous forests of Georgia. The aim of the study was the simultaneous determination of compounds extracted by solvents of different polarities from buds of Populus tremula and their in vitro cytotoxic activity. The components containing in Hexane extract consists of aromatic compounds, sesquiterpene hydrocarbons and sesquiterpenoids. The components containing ethyl acetate extract consist of polyols. The main fraction of the ethylacetate extract consists of acidic compounds of aliphatic and aromatic series. The former is represented by saturated and unsaturated mono-, dicarboxylic and hydroxycarboxylic acids. Cytotoxic studies show, that the Hexane and Ethyl acetate extracts of the buds of P. tremula grown in Georgia have specific cytotoxic activity in cancer cells: A-549 (lung carcinoma), DLD-1 (intestinal adenocarcinoma), WS-1 (human fibroblasts).
References
Stanescu, U.; Hancianu, M.; Cioanca, O.; Aprotosoaie, A.C.; Miron, A. Medicinal Plants From A to Z, revised and added, 3rd ed.; Polirom: Ia¸si, Romania, 2018; ISBN 978-973-46-7240-0.
Victor Kuete, Ean-Jeong Seo, Benjamin Krusche et al. Cytotoxicity and Pharmacogenomics of Medicinal Plants from Traditional Korean Medicine. Evid Based Complement Alternat Med. 2013; 2013: 341724
Scaysbrook T., Greenaway W., and Whatley F. R. (1992), Relation of "antimicrobial" compounds present in poplar bud exudates to disease resistance by poplars. Z. Naturforsch. 47c, 197-200.
Hancianu, M.; Stanescu, U.; Aprotosoaie, C. Pharmaceutical, Pharmacological and Clinical Bases of Phytotherapy; "Gr. T. Popa": Ia¸si, Romania, 2008; Volume 3, ISBN 978-973-7682-68-0.
Royer, M.; Houde, R.; Viano, Y.; Stevanovic, T. Non-wood Forest Products Based on Extractives-A New Opportunity for the Canadian Forest Industry Part 1: Hardwood Forest Species. J. Food Res. 2012, 1, 8.
Bouchard, M. Identification D'utilisations pour le Bouleau à Papier et Le peuplier Faux-Tremble; Enseignement Supérieur, Recherche, Science et Technologie: Quebec, QC, Canada, 2013; pp. 145.
Stanescu, U.; Hancianu, M.; Cioanca, O.; Aprotosoaie, A.C.; Miron, A. Medicinal Plants From A to Z, revised and added, 3rd ed.; Polirom: Ia¸si, Romania, 2018; ISBN 978-973-46-7240-0.
Chi, Y.S.; Jong, H.G.; Son, K.H.; Chang, H.W.; Kang, S.S.; Kim, H.P. Effects of naturally occurring prenylated flavonoids on enzymes metabolizing arachidonic acid: Cyclooxygenases and lipoxygenases. Biochem. Pharmacol. 2001, 62, 11851191.
Greenaway,W.; May, J.; Scaysbrook, T.; Whatley, F.R. Identification by gas chromatography-mass spectrometry of 150 compounds in propolis. Z. Nat. Sect. C J. Biosci. 1991, 46, 111121.
Greenaway, W. Compositions of Bud and Leaf Exudates of Some Populus Species Compared. Z. Nat. C 1992, 47, 329334.
Jerkovic, I.; Mastelic, J. Volatile compounds from leaf-buds of Populus nigra L. (Salicaceae). Phytochemistry 2003, 63, 109113
O'Brien, J., Wilson, I., Orton, T., Pognan, F., 2000. Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity. Eur. J. Biochem. 267, 54215426