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Abstract
Silver nanoparticles have high biological activity due to their small size and big surface. They show antibacterial activity and cytotoxicity on cancer cells. Both the properties and the biological activity of silver nanoparticles depend to a significant extent on the technologies of their preparation. In the given research silver nanoparticles were biosynthesized using a watery extract of Centaurea adzharica Sosn. The approach was chosen based on its safety, low cost, and simplicity of the technology. The synthesis of nanoparticles was observed and proved by Uv-vis spectroscopy. Dynamic light scattering method and Transmission electron microscopy were used to characterize them. Antibacterial activity was evaluated against Gram-negative Escherichia coli, Gram-positive Staphylococcus aureus and antifungal activity on Candida albicans. Their cytotoxic effects were tested on human lung carcinoma A-549, colon adenocarcinoma DLD-1 and healthy human skin fibroblasts WS1 cell lines. Results show that biosynthesized silver nanoparticles have antibacterial, antifungal action and are cytotoxic against tested cancer cell lines.
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