Phytochemical study and evaluation of pharmacological activity of Solanum woronowii, common in Georgia

Abstract

The aim of the research is the phytochemical study of the secondary metabolites of the endemic species of the Caucasus - Solanum woronowii Pojark and the evaluation of their pharmacological activity for use in medicine.

There was studied microstructure of the above-ground vegetative organs; microscopic diagnostic signs of Solanum woronowii leaf and twig have been established; qualitative and quantitative content of secondary metabolites by spectral analysis methods; pharmacological action of secondary metabolites in vitro experiments.

The content of steroidal glycosides, flavonoids and alkaloids in the total extract; furostanol glycosides in the total extract with a content of 11,6%; weak antioxidant activity of secondary metabolites IC<50 g/ml; the total extract have pronounced (IC50 = 20.61 4.89 g/ml) and enriched fraction relatively strong (IC50=18,30 1.23 g/ml) cytotoxic activity in vitro experiment.