Keywords
Epinephrine
Cardiovascular System
Local Anesthetics
Hemodynamics
Dental Anesthesia
Hypertension
Myocardial Infarction
How to Cite
Abstract
Vasoconstrictors are widely used in medical and dental practice, particularly in local anesthetics, to prolong drug efficacy and minimize systemic absorption. While these agents are generally considered safe, concerns have been raised regarding their effects on the cardiovascular system, particularly in patients with pre-existing heart conditions. The study examines the role of vasoconstrictors, their pharmacological mechanisms, and their potential risks and benefits in clinical settings. By analyzing modern literature and clinical guidelines, were provided conclusions and recommendations for the safe use of vasoconstrictors in patients with cardiovascular risks. The study of vasoconstrictors and their impact on cardiac function is a crucial area of cardiovascular research are very challenging in medicine. Vasoconstrictors are substances that cause the narrowing of blood vessels, leading to increased vascular resistance and blood pressure. The paper explores the scientific discourse surrounding the physiological mechanisms through which vasoconstrictors exert their effects on the cardiovascular system, focusing on their role in modulating cardiac output, myocardial oxygen demand, and overall cardiac function. The article delves into the molecular pathways involved, such as the activation of adrenergic receptors, the renin-angiotensin-aldosterone system, and endothelin, as well as their potential therapeutic implications and risks. The review discusses the varying effects of different vasoconstrictors, including naturally occurring substances and synthetic agents, on both normal and pathological cardiac conditions. Finally, it highlights the complex interactions between vasoconstrictors and other pharmacological interventions, suggesting areas for future research to improve therapeutic strategies for managing cardiovascular diseases linked to abnormal vascular tone regulation.
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Clarke, R. J., and D. C. Holt. 2023. "Pharmacokinetics of Vasoconstrictors in High-Risk Populations." British Journal of Clinical Pharmacology 89 (5): 842–56.
Collins, J. A., and K. M. Wright. 2022. "Clinical Guidelines for the Use of Vasoconstrictors in Surgery." Anesthesia & Analgesia 132 (4): 912–28.
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