LOCALIZED SCLERODERMA (CASE REPORT)

Abstract

Localized scleroderma, also known as morphea, is a rare and typically nonsystemic autoimmune disorder. Pathogenesis of localized scleroderma is studied with allowance for metabolic disorders of the connective tissue vascular disorders and autoimmune reactions. Changes in the endothelial cells play a role of triggering factor. Vascular injury causes epithelial cell activation dysfunction and disturbance of capillary permeability, followed by complex interaction between endothelial cell dysfunction and microvascular injury, inflammation, autoimmune responses, and activation of fibroblasts. Localized scleroderma often occurs at the site of injury. We present the analysis of published data on the development of scleroderma after various medical and aesthetic surgeries. We also discuss the development of localized scleroderma after placing silicone mammary gland implants, rhinoplasty, laparoscopy, and vaccination. A case of linear scleroderma in a 55-year-old female patient suffering from autoimmune thyroiditis and obesity was reported. Linear scleroderma developed over the phlebosclerosis site.