MULTIPLE INFLAMMATORY SYNDROME IN CHILDREN (MIS-C) ASSOCIATED WITH COVID-19

MULTIPLE INFLAMMATORY SYNDROME IN CHILDREN (MIS-C) ASSOCIATED WITH COVID-19

Authors

  • TINATIN KUTUBIDZE
  • MAIA KHERKHEULIDZE
  • MANANA KOBAKHIDZE
  • IRINE KEKELIDZE
  • EKA NAKHUTSRISHVILI

DOI:

https://doi.org/10.52340/jecmj.2021.378

Keywords:

covid-19, multiple inflammatory syndrome

Abstract

There is a difference between MIS-C and KD. This is probably a postinfectious inflammatory response manifested with elevation of inflammatory markers and signs of myocardial damage. So, MIS-C could be an analogue of late phase COVID-19, which we are seeing in adult patients. This phase is also characterized by “cytokine storm” and can include severe myocardial disfunction, renal damage and laboratory changes consistent with MAS. Despite growing numbers of children with MIS-C, it still remains as rare condition and has good outcome in majority of cases. Children with MIS-C need special care of rheumatologist, infectious disease and intensive disease specialist collaboration.

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References

Centers for Disease Control and Prevention (CDC). Multisystem inflammatory syndrome (MIS-C). Information for healthcare providers about multisystem inflammatory syndrome in children (MIS-C). Case definition for MIS-C. Available at: https://www.cdc.gov/mis-c/hcp/.Reviewed May 29. 2020. Accessed June 12, 2020.

Riphagen S, Gomez X, Gonzalez-Martinez C, Wilkinson N, Theocharis P. Hyperinflammatory shock in children during COVID-19 pandemic. Lancet. May 7, 2020. Epub ahead of print. doi: 10.1016/S0140-6736(20)31094-1

Standford T. Shulman, MD , Leonard R. Krilov, MD. Multisystem inflammatory syndrome in children associated with COVID-19. Contemporary PEDS Journal, July 13, 2020, Vol 37 No 7, Volume 37, Issue

Leora R. Feldstein, Ph.D., Erica B. Rose, Ph.D, et al. Multisystem Inflammatory Syndrome in U.S. Children and Adolescents. N Engl J Med 2020; 383:334-346. July 23, 2020

Verdoni L, Mazza A, Gervasoni A, et al. An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study. Lancet. May 13, 2020. Epub ahead of print. doi: 10.1016/S0140-6736(20)31103-X

World Health Organization (WHO). Coronavirus disease (COVID-19). Situation report—138. Available at: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200606-covid-19-sitrep-138.pdf?sfvrsn=c8abfb17_4. Published June 6, 2020. Accessed June 12, 2020.

New York State. Novel coronavirus. Childhood inflammatory disease related to COVID-19. Available at: https://coronavirus.health.ny.gov/childhood-inflammatory-disease-related-covid-19. Updated June 12, 2020. Accessed June 12, 2020.

NIH observational study of coronavirus infection and multisystem inflammatory syndrome in children begins. Wednesday, December 16, 2020

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Published

2021-07-07

How to Cite

TINATIN KUTUBIDZE, MAIA KHERKHEULIDZE, MANANA KOBAKHIDZE, IRINE KEKELIDZE, & EKA NAKHUTSRISHVILI. (2021). MULTIPLE INFLAMMATORY SYNDROME IN CHILDREN (MIS-C) ASSOCIATED WITH COVID-19 . Experimental and Clinical Medicine Georgia, (3). https://doi.org/10.52340/jecmj.2021.378

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