PHARMACEURICAL FORMULA AND TECHNOLOGY DEVELOPMENT OF GREEN TEA GRANULES

PHARMACEURICAL FORMULA AND TECHNOLOGY DEVELOPMENT OF GREEN TEA GRANULES

Authors

  • NINO TSAGAREISHVILI
  • NINO KURDIANI
  • KRISTINE TSKHVARADZE
  • NINO IMNADZE

DOI:

https://doi.org/10.52340/jecm.2022.07.30

Keywords:

green tea, granules, production, technology

Abstract

The production of products with well-balanced biologically active compounds is one of the main tasks of the present day. The green tea raw product causes the high interest from this point of view and gives the opportunity to develop the biologically valuable product. In comparison with other types of tea, does not undergo to fermentation and keep the important useful agents. Was developed the formula of green tea granules by using the chopped raw material and its dry extract: (1) The chopped leaves of green tea- 0.5% PVP water solution (1:1); (2) The dry extract of green tea – 0.5% PVP ethanol solution (96% alcohol) (1:0.5).  Based on the conducted studies was developed the optimal technology of green tea granules reception, which has the following flow steps: 1. Grinding; sieving (≤1mm fraction separation); mixing with the granulating agent (0.5% PVP water solution); granulation to 2 mm; Drying (at 40-50°С temperature); standardisation, packaging, labelling. 2. Extraction I (at 90°С for 0.5 hrs, in ratio 1:20); filtration I; Extraction II (at 90°С for 0.5 hrs, in ratio 1:20); filtration II; mixing (filtrate I and filtrate II); thickening; drying (at 60°С), mixing with the granulating agent (0.5% PVP ethanol solution); granulation to 2 mm; drying at room temperature; standardisation; packaging, labelling. Experimentally was determined the technological and physic-chemical properties of received granules. Established the accordance of these characteristics to the appropriate specification.

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References

Балакина М.В., Охотникова В.Ф. Гранулы как перспективная лекарственная форма // Сб. науч. трудов I-й Научно-практической конференции аспирантов и молодых ученых «Молодые ученые и фармация XXI века». М.:ВИЛАР. 2013. С. 12−14.

Senanayake SPJN. Green tea extract: Chemistry, antioxidant properties and food applications – A review. J Funct Foods, 2013

Fung KF, Zhang ZQ, Wong JWC, Wong MH: Aluminum andfluoride concentrations of the three tea varieties growing at Lan-tau Island, Hong Kong. 2003

Vayalil P. K., Mittal A., Hara Y. et al. Green tea polyphenols prevent UV light induced oxidative damage and matrix metalloproteinases expression in mouse skin. J Invest Dermatol 2004

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Published

2022-10-27

How to Cite

TSAGAREISHVILI , N. ., KURDIANI , N. ., TSKHVARADZE , K. ., & IMNADZE , N. . (2022). PHARMACEURICAL FORMULA AND TECHNOLOGY DEVELOPMENT OF GREEN TEA GRANULES . Experimental and Clinical Medicine Georgia, (7). https://doi.org/10.52340/jecm.2022.07.30

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