FORMULATION, TECHNOLOGY AND BIOPHARMACEUTICAL EVALUATION  OF A PLANTAIN CREAM

LASHA BAKURIDZE; DALI BERASHVILI; TAMAZ TCHUMBURIDZE; LAMZIRA EBRALIDZE; MARIAM CHKONIA; KETEVAN NATOBIDZE; ALIOSHA BAKURIDZE

doi:10.52340/jecm.2023.04.22

FORMULATION, TECHNOLOGY AND BIOPHARMACEUTICAL EVALUATION OF A PLANTAIN CREAM

Authors

LASHA BAKURIDZE Tbilisi State Medical University
DALI BERASHVILI Tbilisi State Medical University
TAMAZ TCHUMBURIDZE Tbilisi State Medical University
LAMZIRA EBRALIDZE Tbilisi State Medical University
MARIAM CHKONIA Tbilisi State Medical University
KETEVAN NATOBIDZE Tbilisi State Medical University
ALIOSHA BAKURIDZE Tbilisi State Medical University

DOI:

https://doi.org/10.52340/jecm.2023.04.22

Keywords:

Plantain cream, formulation, technology, biopharmaceutical research

Abstract

The Georgian market is oversaturated with cosmetics from different countries, which are mainly prepared using synthetic substances. Their long-term consumption may lead to a number of undesirable consequences. Based on this, it is advisable to create new, competitive natural products based on plant raw materials. Among the available medicinal plants in Georgia, Plantago major is of particular interest. It is used against skin aging. The polysaccharides, flavonoids and other phenolic compounds represented in it increase the elasticity and firmness of the skin.

The aim of the research is to determine the formulation of Plantain cream and develop the technology based on biopharmaceutical research.

On the basis of the conducted biopharmaceutical studies, the formulation of w/o type emulsion creams containing plantain thick extract and polysaccharides has been determined and the technology has been developed. The provided creams are characterized by optimal quality indicators.

The structural-mechanical properties of w/o type emulsion creams containing plantain thick extract and polysaccharides have been determined. The supplied creams have optimal consumer properties. Creams containing the sum of plantain thick extract and polysaccharides do not have osmotic activity; Microscopic studies have established that creams containing the sum of plantain thick extract and polysaccharides are polydisperse; By studying the storage stability of creams containing plantain thick extract and sum of polysaccharides under different conditions, it is established that the supplied creams maintain the main quality indicators during the entire period of the study (6 months).

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