INSOMNIA IN PATIENTS WITH URTICARIA AND ATOPIC DERMATITIS

ZAZA  TELIA; KETEVAN  MACHAVARIANI; ALEXANDER Z.  TELIA; ALEXANDER A.  TELIA

doi:10.52340/jecm.2022.07.20

INSOMNIA IN PATIENTS WITH URTICARIA AND ATOPIC DERMATITIS

Authors

ZAZA TELIA
KETEVAN MACHAVARIANI
ALEXANDER Z. TELIA
ALEXANDER A. TELIA

DOI:

https://doi.org/10.52340/jecm.2022.07.20

Keywords:

Insomnia, urticaria, atopic dermatitis

Abstract

Insomnia affects a considerable number (10-20%) of people worldwide. Many primary clinical diseases may underlie the occurrence of these symptoms. Among them may be atopic dermatitis (AD) and chronic spontaneous urticarial (CSU). A causal relationship between these two pathological conditions has not yet been established. We were tasked with studying the relationship between sleep disorders, AD and CSU, and determining the feasibility of adding this risk factor to the previous two (anxiety and depression) to increase their combined predictive power. The study was conducted in 2020-2021 years. at the clinics of TSMU. The study included 180 patients (men 56, women 124) suffering from AD (74) and CSU (106); we could reject the null hypothesis of an association between sleep disturbances and AD and CSU. It was found that individuals with atopic dermatitis and chronic urticaria had significant sleep disturbances compared with the control group. Therefore, we consider it reasonable to conduct additional repeated studies on more homogeneous scientific groups.

Downloads

Download data is not yet available.

References

Caroline M. Matthias D. Hans-Günter W. Petra S., Sleep Disturbance in Patients with Urticaria and Atopic Dermatitis: An Underestimated Burden. Acta Derm Venereol 2020; 100: adv00073;

Gaig P, Olona M, Munoz Lejarazu D, Caballero MT, Dominguez FJ, Echechipia S, et al. Epidemiology of Urticaria in Spain. Journal of Investigational Allergology & Clinical Immunology 2004; 14(3):214‐20. [PUBMED: 15552715];

Hanifin M, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol 1980; suppl 92: 44–47;

Hellgren L. The prevalence of urticaria in the total population. Acta Allergologica 1972; 27(3):236‐40. [MEDLINE: 4678809];

Henriette R. Katja B. Andrea Bauer. Treatment satisfaction in chronic urticaria during guideline-based therapy. Journal of the German Society Dermatology. DOI: 1111/ddg.14415. 1610-0379/2021;

Hye-Jin Ahn1, et al. l. Bark-Lynn Lew5 Cross-sectional study of psychiatric comorbidities in patients with atopic dermatitis and nonatopic eczema, urticaria, and psoriasis. Neuropsychiatric Disease and Treatment 2019:15 1469–1478;

Irwin MR, Olmstead R, Carroll JE. Sleep disturbance, duration, and inflammation: a systematic review and meta-analysis of cohort studies and experimental sleep deprivation. Biol Psychiatry 2016; 80: 40–52;

Jensen P, Zachariae C, Skov L, Zachariae R. Sleep disturbance in psoriasis: a case-controlled study. Br J Dermatol 2018; 179: 1376–1384;

Kaaz K, Szepietowski JC, Matusiak L. Influence of itch and pain on sleep quality in atopic dermatitis and psoriasis. Acta Derm Venereol 2019; 99: 175–180;

Kaaz K, Szepietowski JC, Matusiak L. Influence of itch and Pain on sleep quality in patients with hidradenitis suppurativa. Acta Derm Venereol 2018; 98: 757–761;

Kulthanan K, Chiawsirikajorn Y, Jiamton S. Acute urticaria: etiologies, clinical course and quality of life. Asian Pac J Allergy Immunol 2008; 26: 1–9;

Levin J, Friedlander SF, Del Rosso JQ. Atopic dermatitis and the stratum corneum: part 2: other structural and functional characteristics of the stratum corneum barrier in atopic skin. J Clin Aesthet Dermatol 2013; 6: 49-54;

Maurer M, Staubach P, Raap U et al. ATTENTUS, a German online survey of chronic urticaria patients highlighting the burden of disease, unmet needs and real-life clinical practice. Br J Dermatol 2016; 174(4): 892-4;

Maurer M, Weller K, Bindslev‐Jensen C, Gimenez‐Arnau A, Bousquet PJ, Bousquet J, et al. Unmet clinical needs in chronic spontaneous urticaria. A GA(2)LEN task force report. Allergy: European Journal of Allergy and Clinical Immunology 2011; 66(3):317‐30. [EMBASE: 2011077490];

Miner B, Kryger MH. Sleep in the aging population. Sleep Med Clin 2017; 12: 31–38;

Morin CM; Belleville G; Bélanger L; Ivers H. The insomnia severity index: psychometric indicators to detect insomnia cases and evaluate treatment response. SLEEP 2011; 34(5):601-608;

Reich A, Heisig M, Phan NQ, Taneda K, Takamori K, Takeuchi S, et al. Visual analogue scale: evaluation of the instrument for the assessment of pruritus. Acta Derm Venereol 2012; 92: 497–501;

Sarbijt S. Chronic urticaria: clinical manifestations, diagnosis, pathogenesis, and natural history. www.uptodate.com/contents/chronic urticarial clinical manifestations diagnosis pathogenesis and natural history/ source=see_link&anchor=H23#H25) (accessed 13 March 2014);

Telia Z., Аnxiety and depression in predicting the risk of chronic spontaneous urticaria (CSU) and atopic dermatitis (AD), in publish.