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Abstract
It has been established that the immunomodulators Una de Gato and Phenovin have no effects on intact Jurkat cells. Adding Una de Gato and Phenovin to the incubation area of Jurkat cells in oxidative/ nitrogen stress condition revealed their expressed antioxidative activity, increased the activity of superoxiddismutasa and intensity of mitochondrial respiration in cells on the background of reduction of lipoperoxid radicals and free nitrogen oxidation. Treatment of periodontitis with the above-mentioned preparations reduced superoxide-radical content and increased NO synthesis system activity in patients, number of microbes and replacement of gram-negative micro-flora with gram-positive flora has been observed. This process was more intensive in patients who underwent immunomodulation. Clinico-functional studies have revealed that the effect of treatment in patients who underwent immunomodulation was much higher.
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