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Abstract
Narcotization with homemade psychostimulant “Jeff” is a significant threat to the population of Georgia in the recent years, due to availability of medicines necessary for preparation, low price, simple, short-term technology of production and the strongest narcotic and toxic effect of the received mixture. A toxic (ephedrone) encephalopathy is characterized by the development of severe, almost irreversible neurological, affective and cognitive disorders, resulting in the disability of users of this homemade stimulants and a significant decline in their quality of life. The goal of our investigation was study of affective disorders in the users of homemade stimulants of ephedrone group and assess their changes in case of inclusion medication Thiogamma in the standard treatment process. 35 patients, aged 20-65, of male gender, who were hospitalized in the clinic Neogen after cessation of Epodhrone (“Jeff”) have been investigated. Patients were selected and diagnosed according to criteria provided by ICD-10. The study was carried out in accordance with the Biotech principles, based on the informed consent. 35 Patients with diagnosis: mental and behavioral disorders caused by the use of ephedrine, withdrawal syndrome, ephedrone encephalopathy, were selected in two groups. Main study group-I _ during standard treatment was included medication Thiogamma, 600 mg daily dose, initially by drip-feed and then in tablet form. Control group-II - The standard treatment included a placebo drug. Before the start of treatment and after 1 month, affective disorders of all patients were measured by Beck’s Depression Scale and Spilberger’s situational and personal anxiety scale. Before treatment patients from both study groups have shown mild, moderate and higher than moderate levels of depression; no patient has shown severe depression. The moderate and high personal anxiety, as well as low, moderate and high situational anxiety indexes were shown. As a result of treatment, patients in both groups had got positive dynamics in terms of changes in depression and anxiety level, but the improvement is more evident in patients from the main study group-I, whose treatment involved the preparation Thiogamma along with the standard medications. The above mentioned results indicate the effectiveness of the preparation Thiogamma in the treatment of disorders caused by the use of homemade stimulants (“Jeff”).
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