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Abstract
Beekeeping is one of the oldest branches of agriculture, which is of particular importance in the pharmacy and food industry. Bees provide a variety of specific products, including bee milk, which contains essential amino acids, vitamins (B1, B2, B5, B6, B12, A, D, PP, E, D) and microelements. Bee products should be free of any chemical contamination and safe for human health. Particularly noteworthy is the fact that in recent years there has been an excessive increase in pesticides (dimethoate, deltamethrin, cypermethrin, etc.) in agriculture. Given this, bee milk may contain pesticides from nectar collected from various plants. Accordingly, for the analysis of residual pesticides in bee products, the development of high sensitivity and specific methods is an important task of modern pharmacy and toxicology. Based on this study, optimum conditions for the extraction of deltamethrin and cypermethrin from bee milk have been elaborated - QuEChERS Cartridge # 2, which provides rapid and effective extraction of the target substance (within 87-88%). According to the experimental data, optimum conditions for the quantitative determination of deltamethrin and cypermethrin in bee milk were determined by GC-MS method. The method was validated on following parameters is linearity (calibration concentration 50 - 800 ng / ml, correlation coefficient – cypermethrin R2 = 0.9980, deltamethrin R2 = 0.9961); selectivity; LOD (17.35 ng / ml - 18.42 ng / ml) and LOQ (52.13 ng / ml - 55.27 ng / ml) with precision and accuracy.