ADVANCED GLYCATION END PRODUCTS
Advanced glycation end products (AGEs) are cohort of heterogeneous compounds that are formed after the non-en- zymatic glycation of proteins, lipids and nucleic acids. AGEs play an important role in the generation of a state of oxidative stress and chronic inflammation, which underlies most modern chronic diseases, including diabetes, cardiovascu- lar disease, neurodegeneration. AGEs can be formed exoand endogenously. They exert their deleterious effect by receptor-dependent and receptor-independent mechanisms. Since the emergence of AGEs as an important pathogenic factor in many diseases and aging the development of strategies against AGEs is in the center of scientific interest, as well as improvement in health care and lifestyle.
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