Keywords
How to Cite
Abstract
Advanced glycation end products (AGEs) are cohort of heterogeneous compounds that are formed after the non-en- zymatic glycation of proteins, lipids and nucleic acids. AGEs play an important role in the generation of a state of oxidative stress and chronic inflammation, which underlies most modern chronic diseases, including diabetes, cardiovascu- lar disease, neurodegeneration. AGEs can be formed exoand endogenously. They exert their deleterious effect by receptor-dependent and receptor-independent mechanisms. Since the emergence of AGEs as an important pathogenic factor in many diseases and aging the development of strategies against AGEs is in the center of scientific interest, as well as improvement in health care and lifestyle.
References
. Abate G., DelbarbaA., Marziano M, et al. Advanced Glycation End Products (AGEs) in food: Focusing on Mediterranean Pasta. Nutrution& Food Sciences, 2015, 5:6
Alin Stirban, Thomas Gawlowski, Michael Roden, Vascular effects ofadvanced glycation end products: Clinical effects and molecular mechanisms. Molecular metabolism, 2013, 7;
(2):94-10. 3. Caram LMO, Ferrari R, Rasslan Z., Advanced Glycation End Products(AGEs) and Its Soluble Receptor in Smokers and Mi ld/Moderate COPD. Journal of Lung Disease&Treatment.2016,2:3
Christiane Ott, Kathleen Jacobs.et al., Role of advanced glycation end products in cellular signaling. Redox Biology, 2014, 2:411-29.
Eui-Young Choi, Hyuck Moon Kwon, Chul-Woo Ahn, et al., Serum Levels of Advanced Glycation End Producys Are Associated With In-Stent Restenosis in Diabetic Patients. Yonsey Medical Journal, 2005, Feb 28; 46(1): 78–85.
Kalina Rajaobelina, Audrey Cougnard-Gregoire,et al., Autofluorescence of Skin Advanced Glycation End Products: Marker of Metabolic Memory in Elderly Population. J Geron A Sci Med, 2015, 70(7):841-6.
Jalaluddin Mohd, Saheem Ahmad et.al, Recent Advances in Detection of AGEs: Immunochemical, Bioanalytical and Biochemical Approaches. International Union of Biochemistry and Molecular Biology. 2015, 67 (12), 897-913.
Jaime Uribarri, John Cijiang He, The Low AGE Diet: A Neglected Aspect of Clinical Nephrology Practice? Nephron 2015,130 (1):48-53
Jaime Uribarri, Sandra Woodruff, et al. Advanced Glycation End Products in Foods and a Practical Guide to Their Reduction in Diet. J Am Diet Assoc. 2010, 1
(6): 911– 16.e12. 10Helen Vlassara and Jaime Uribarri, Advanced Glycation End Products (AGE) and Diabetes: Cause, Effect, or Both. Curr Diab Rep. 2014, 14(1): 453. 11.Paraskevi Gkogkolou and Markus Bohm, Advanced glycation end products - Key players in skin aging? Dermatoendocrinol. 2012,4(3):259-70. 12.Paul J. Thornalley, Naila Rabbani, Detection of Oxidized and glycated proteins in clinical samples using mass spectrometry - A user’s perspective. Biochemica et Biophisica Acta 1840, 2014, 818-829.