BROMHEXINE HYDROCHLORIDEINHALATION EFFERVESCENT POWDERFORMULATION AND TECHNOLOGY

How to Cite

Kveselava , M., Bakuridze , L., Ebralidze , L., Mosidze , E., & Bakuridze , A. (2023). BROMHEXINE HYDROCHLORIDEINHALATION EFFERVESCENT POWDERFORMULATION AND TECHNOLOGY. Collection of Scientific Works of Tbilisi State Medical University, 55, 87–90. Retrieved from https://journals.4science.ge/index.php/CSW/article/view/1431

Abstract

Bromhexine hydrochloride dry effervescent powder canbe used in combination therapy for the treatment of bronchi-tis, bronchiectasis and asthma.The study aimed to determine the recipe for the composi-tion of the dry inhalation effervescent powder of bromhex-ine hydrochloride and to develop the technology.Based on technological studies, the optimal conditionsfor the recrystallization of bromhexine hydrochloride weredetermined using an antisolvent agent, which ensures theformation of particles of desirable size, also increase in loose-ness and flow;The effect of surfactants (plant saponins) on the solubil-ity of bromhexine hydrochloride in water has been studied.It was determined, that extracts of Saponaria and Yucca tak-en in 6 times higher amounts increase the solubility of theactive pharmaceutical ingredient, which is not desirable.Meanwhile, based on the conducted studies, the conver-sion of the substance to the “effervescent” powder was con-sidered as a contributing factor to the solubility.Based on biopharmaceutical studies excipients were se-lected: substances of alkaline and acidic nature, beta-cyclo-dextrin as a “matrix-carrier”, against cohesion - cholesterol.Formulation of bromhexine hydrochloride effervescent, in-halation powder was developed. The combination of cyclo-dextrin and cholesterol ensures to achieve high looseness,flow, while the powder is not characterized by the formationof conglomerates.Studies using the “Handihaler” inhaler and the artificiallung (Andersen cascade impactor) have shown that the elab-orated formula of bromhexine hydrochloride inhalation ef-fervescent powder is fully evacuated from the gelatin cap-sules and is optimally distributed over the entire area of thebronchial tree.Using a laser diffractometer, it was found that the size of30% of the inhalation effervescent powder of bromhexinehydrochloride ranges between 1 to 5 ìm, which confirms thepossibility of its distribution as well as to the upper and soto lower respiratory tract.Technological scheme of preparation of bromhexine hy-drochloride inhalation effervescent powder in gelatin cap-sules was developed for “Handihaler” inhaler

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