Malignant peripheral nerve sheet tumors (MPNST) are uncommon and rare condition. These neoplasms are often associated with neurofibromatosis type I (NF-I) but can also occur sporadically. This article presents a rare case report discussing the detailed diagnostic approach along with an extensive review of the literature for malignant peripheral nerve sheath tumor arising in the left gluteus. A 16 years old boy presented with a large tumor in left gluteus. The patient noticed mass in the left gluteus several years earlier. Patient was complaining about a growing lump tissue under the skin, pain, loss of control of muscles in left leg. Biopsy of the left gluteus showed malignant neoplasm and malignant nerve sheet tumor components were predominant. Surgery was performed with total resection. The operation was performed under general anesthesia. An elliptical incision was made on the tumor and the pathological center was found and released from the surrounding tissues. Pathological blood vessels were clamped and cut. A detailed revision was made and the tumor was removed within healthy tissues. Tumor size was 20X25X20-cm. The patient underwent rehabilitation successfully. No recurrence has been observed in the last 4 years.
Malignant Peripheral Nerve Sheath Tumors—A Comprehensive Review of Pathophysiology, Diagnosis, and Multidisciplinary Management Samantha W. E. Knight, Tristan E. Knight, Teresa Santiago, Andrew J. Murphy, and Abdelhafeez H. Abdelhafeez I. Amirian E.S., Goodman J.C., New P., Scheurer M.E. Pediatric and Adult Malignant Peripheral Nerve Sheath Tumors: An Analysis of Data from the Surveillance, Epidemiology, and End Results Program. J. Neuro-Oncol. 2014;116:609–616. doi: 10.1007/s11060-013- 1345-6.
Malignant Peripheral Nerve Sheath Tumor: Models, Biology, and Translation Bandarigoda N. Somatilaka,I Ali Sadek, I Renee M. McKay, I and Lu Q. Le Pekmezci M, Reuss DE, Hirbe AC, Dahiya S, Gutmann DH, von Deimling A et al. Morphologic and immunohistochemical features of malignant peripheral nerve sheath tumors and cellular schwannomas. Mod Pathol 2015; 28: 187–200.
Miettinen MM, Antonescu CR, Fletcher CDM, Kim A, Lazar AJ, Quezado MM et al. Histopathologic evaluation of atypical neurofibromatous tumors and their transformation into malignant peripheral nerve sheath tumor in patients with neurofibromatosis 1-a consensus overview. Hum Pathol 2017; 67: 1–10
Malignant Peripheral Nerve Sheath Tumors MOHAMAD. A FARID, ELIZABETH G. DEMICCO, ROBERTO GARCIA, LINDA AHN, PAMELA R. MEROLA, ANGELA CIOFFI, ROBERT G. MAKI Tisch Cancer Institute, Mount Sinai School of Medicine, New York, New York, USA Disclosures of potential conflicts of interest may be found at the end of this article.
Malignant Peripheral Nerve Sheath Tumors MOHAMAD FARID, ELIZABETH G. DEMICCO, ROBERTO GAR- CIA, LINDA AHN, PAMELA R. MEROLA, ANGELA CIOFFI, ROBERT G. MAKI Tisch Cancer Institute, Mount Sinai School of Medicine, New York, New York, USA
Ferner RE, Golding JF, Smith M et al. [18F]2- fluoro-2-deoxy-D-glucose positronemission tomography (FDG PET) as a diagnostic tool for neurofibromatosis 1 (NF1) associated malignant peripheral nerve sheath tumours (MPNSTs): A long-term clinical study-Department of Neurology, Guy’s and St Thomas’ NHS Foundation Trust, Kings College London, London, UK. firstname.lastname@example.org
Scaife CL, Pisters PW. Combined-modality treatment of localized soft tissue sarcomas of the extremities. Surg Oncol Clin N Am 2003; 12: 355–368. [PubMed: 12916459]
Bates JE, Peterson CR, Dhakal S, Giampoli EJ, Constine LS. Malignant peripheral nerve sheath tumors (MPNST): a SEER analysis of incidence across the age spectrum and therapeutic interventions in the pediatric population. Pediatr Blood Cancer 2014