SOLUBLE EPOXIDE HYDROLASE AS A NEW TARGET FOR THERAPEUTIC INTERVENTION

Authors

  • Gongadze N. გონგაძე ნ.
  • Gabunia L. გაბუნია ლ.
  • Mirziashvili M. მირზიაშვილი მ.
  • Gvishiani M. გვიშიანი მ.
  • Archvadze A. არჩვაძე ა.

DOI:

https://doi.org/10.52340/csw.2015.49.0.34-36

Abstract

Soluble epoxide hydrolase (sEH) – a bifunctional homodimeric enzyme located in both cytosol and peroxisomes (2, 23, 24) was identified in plants and mammals (19). sEH facilitates the conversion of epoxyeicosatrienoic acids (EETs) to the biologically less active dihydroxyeicosatrienoic acids (DHETs). Unlike prostaglandins, the EETs and DHETS can be incorporated into phospholipids, which then act as storage sites (10). The sEH is thought to take part largely in the metabolism of arachidonic, linoleic and other fatty acid epoxides, endogenous chemical mediators playing an important role in blood pressure regulation and inflammation (20, 21). It has been shown that inhibition of sEH by trans-4[4(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid (t-AUCB) may lead to elevation of EETs level which in turn could elicit various beneficial biological effects in different conditions, such as hypertension, pulmonary diseases, diabetes, atherosclerosis, inflammation etc (9, 10). It was established that EETs are synthesized in endothelial cells and may lead to vasodilation by activating the smooth muscle large conductance Ca 2+ activated K channels, resulting in smooth muscle cell hyperpolarization in a number of vascular beds (3, 14).

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References

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Published

2019-07-01

How to Cite

გონგაძე ნ. G. N., გაბუნია ლ. G. L., მირზიაშვილი მ. M. M., გვიშიანი მ. G. M., & არჩვაძე ა. A. A. (2019). SOLUBLE EPOXIDE HYDROLASE AS A NEW TARGET FOR THERAPEUTIC INTERVENTION. COLLECTION OF SCIENTIFIC WORKS OF TBILISI STATE MEDICAL UNIVERSITY, 49, 34–36. https://doi.org/10.52340/csw.2015.49.0.34-36

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