The role of vitamin D3 deficiency in the etiopathogenesis of autoimmune thyroid diseases
DOI:
https://doi.org/10.52340/spectri.2023.10Abstract
Vitamin D is now recognized not only for promoting bone health in children and adults, but also for other health benefits, including reducing the risk of chronic diseases such as autoimmune diseases, malignancies, and cardiovascular disease. The aim of our study is to investigate whether there is a correlation between autoimmune thyroid disease and vitamin D 3 deficiency in the population of Georgia. The study cohort included a total of 306 patients aged 18–65 years (mean age 37.6 ± 11.3 years) referred to the National Institute of Endocrinology from 2018 to 2019The cohort included 87 men (total 28.4%) and 219 women (total 71.6%). A retrospective selection of the study population was made based on patient history. The study protocol was approved by the Medical Ethics Committee of our institute (Protocol N 448) and informed consent was signed by all patients. Results: Compared to controls the study droup were characterized by significantly higher frequencies of following factors: hair loss, brittle nails, dizziness, general weakness, mood swings. Compared to controls the study group were characterized by significantly higher frequencies of Anti-TPO (236.44+44 vs 0.409.65+84.22, p<0.0001). The mean value of vitamin D and TSh are unsatisfactory higher in the study group(6.1+8.64 vs 5.6+9.20, p=0.5161).
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References
Adams JS, Hewison M. Update in vitamin D. The Journal of Clinical Endocrinology & Metabolism. 2010 Feb 1;95(2):471-8.
Azzam AY, Ghozy S, Azab MA. Vitamin D and its' role in Parkinson's disease patients with SARS-CoV-2 infection. A review article. Interdisciplinary Neurosurgery. 2022 Mar 1;27:101441.
Tsiaras WG, Weinstock MA. Factors influencing vitamin D status. Acta Dermato Venereologica. 2011 Mar 1;91(2):115.
Holick MF. Vitamin D status: measurement, interpretation, and clinical application. Annals of epidemiology. 2009 Feb 1;19(2):73-8
Bikle D. Nonclassic actions of vitamin D. The Journal of Clinical Endocrinology & Metabolism. 2009 Jan 1;94(1):26-34.
Meza-Meza MR, Ruiz-Ballesteros AI, de la Cruz-Mosso U. Functional effects of vitamin D: From nutrient to immunomodulator. Critical Reviews in Food Science and Nutrition. 2022 Jun 17;62(11):3042-62.
Lerner A, Jeremias P, Matthias T. The world incidence and prevalence of autoimmune diseases is increasing. Int J Celiac Dis. 2015 Nov 16;3(4):151-5.
McLeod DS, Cooper DS. The incidence and prevalence of thyroid autoimmunity. Endocrine. 2012 Oct;42(2):252-65.
Franco JS, Amaya-Amaya J, Anaya JM. Thyroid disease and autoimmune diseases. In: Anaya
Shoenfeld Y, Rojas-Villarraga A, et al., editors. Autoimmunity: From Bench to Bedside [Internet]. Bogota (Colombia): El Rosario University Press; 2013 Jul 18. Chapter 30.
Kacharava T, Giorgadze E, Janjgava S, Lomtadze N, Taboridze I. Correlation between Vitamin B12 Deficiency and Autoimmune Thyroid Diseases. Endocrine, Metabolic & Immune Disorders-Drug Targets (Formerly Current Drug Targets-Immune, Endocrine & Metabolic Disorders). 2023 Jan 1;23(1):86-94.
Dong YH, Fu D2. Autoimmune thyroid disease: mechanism, genetics and current knowledge.
Eur Rev Med Pharmacol Sci. 2014 Jan 1;18(23):3611-8
Sattler S. The Role of the Immune System Beyond the Fight Against Infection. Adv Exp Med Biol. 2017;1003:3-14.
Gombart, A.F.; Pierre, A.; Maggini, S. A Review of Micronutrients and the Immune System–Working in Harmony to Reduce the Risk of Infection. Nutrients 2020, 12, 236.
Niepomniszcze H, Amad RH. Skin disorders and thyroid diseases. Journal of endocrinological investigation. 2001 Sep;24(8):628-38.
Kasumagić-Halilović E. Thyroid autoimmunity in patients with alopecia areata. Acta Dermatovenerol Croat. 2008;16(3):123-5.
Lok U, Hatipoglu S, Gulacti U, Arpaci A, Aktas N, Borta T. The role of thyroid and parathyroid metabolism disorders in the etiology of sudden onset dizziness. Med Sci Monit. 2014 Dec 16;20:2689-94.
Mazokopakis EE, Kotsiris DA. Hashimoto's autoimmune thyroiditis and vitamin D deficiency. Current aspects. Hellenic Journal of Nuclear Medicine. 2014 Jan-Apr;17(1):37-40
Shin DY, Kim KJ, Kim D, Hwang S, Lee EJ. Low serum vitamin D is associated with anti-thyroid peroxidase antibody in autoimmune thyroiditis. Yonsei medical journal. 2014 Mar 1;55(2):476-81.
Gaitonde DY. Hypothyroidism: an update. South African Family Practice. 2012 Sep 1;54(5):384-90.
Stewart R, Hirani V. Relationship between vitamin D levels and depressive symptoms in older residents from a national survey population. Psychosomatic Medicine. 2010 Sep 1;72(7):608-12.
El-Shafie KT. Clinical presentation of hypothyroidism. J Family Community Med. 2003;10(1):55-58
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