Correlation of hyperinsulinemia with diseases of the gastrointestinal tract and the level of electrolytes in blood serum
DOI:
https://doi.org/10.52340/spectri.2023.12Keywords:
insulin, hyperinsulinemia, gastrointestinal tract, ZnAbstract
The aim of our research is to determine the correlation of insulin resistance with diseases of the gastrointestinal tract and the level of trace elements in blood serum. Metods: The study cohort included a total of 413 patients aged 20–75 years (mean age 37.3 ± 11.4 years) referred to the National Institute of Endocrinology from 2017 to 2019The cohort included 120 men and 293 women . A retrospective selection of the study population was made based on patient history, where hyperinsulinemia was diagnosed. We considered fasting hyperinsulinemia in blood serum as compensatory hyperinsulinemia during insulin resistance. On the basis of which, we included individuals with hyperinsulinemia in the study group of insulin resistance, while the control group consisted of 161 subjects with normoinsulinemia.
Downloads
References
Freeman AM, Pennings N. Insulin Resistance. 2021 Jul 10. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. PMID: 29939616.
Sperling LS, Mechanick JI, Neeland IJ, Herrick CJ, Despres JP, Ndumele CE, Vijayaraghavan K, Handelsman Y, Puckrein GA, Araneta MR, et al. (2015). The CardioMetabolic Health Alliance: Working Toward a New Care Model for the Metabolic Syndrome. J Am Coll Cardiol 66, 1050–1067.
Lomtadze N, Giorgadze E, Janjgava S, Kacharava T, Taboridze I. "The relationship between Insulin Resistance and Thyroid Volume in Georgia". Endocr Metab Immune Disord Drug Targets. 2023 Feb 20.
Grundy SM, Hansen B, Smith SC, Jr, et al. American Heart Association, National Heart, Lung, and Blood Institute, American Diabetes Association. Clinical management of metabolic syndrome: report of the American Heart Association/National Heart, Lung, and Blood Institute/American Diabetes Association conference on scientific issues related to management. Arterioscler Thromb Vasc Biol 2004; 24(2): e19–e24
Heng T.O. Cardiac syndrome X versus metabolic syndrome X. Int. J. Cardiol. 2006;119:137–138.
Sarafidis PA, Nilsson PM. The metabolic syndrome: a glance at its history. J Hypertens. 2006;24(4):621–626.
Swarup S., Zeltser R. Metabolic Syndrome. StatPearls Publishing; Treasure Island, FL, USA: 2020
Defronzo R.A. Banting Lecture. From the triumvirate to the ominous octet: A new paradigm for the treatment of type 2 diabetes mellitus. Diabetes. 2009;58:773–795.
Freeman AM, Pennings N. Insulin Resistance. 2021 Nov 15. In: StatPearls [Internet].
Czech MP. Insulin action and resistance in obesity and type 2 diabetes. Nat Med. 2017 Jul 11;23(7):804-814.
Cano-Ibáñez N., Gea A., Martínez-González M.A., Salas-Salvadó J., Corella D., Zomeño M.D., Romaguera D., Vioque J., Aros F., Wärnberg J., et al. Dietary diversity and nutritional adequacy among an older Spanish population with metabolic syndrome in the PREDIMED-plus study: A cross-sectional analysis. Nutrients. 2019;11:958.
Fahed G, Aoun L, Bou Zerdan M, Allam S, Bou Zerdan M, Bouferraa Y, Assi HI. Metabolic Syndrome: Updates on Pathophysiology and Management in 2021. Int J Mol Sci. 2022 Jan 12;23(2):786.
Aaronson S. Growth factors and cancer. Science (Washington, DC) 1991; 1146– 53.
Martinez J, Sanchez-Paya J, Palazon JM, Suazo-Barbona J, Robles-Diaz G, Perez-Mateo M. Is obesity a risk factor in acute pancreatitis? A meta-analysis. Pancreatology 2004; 4: 42– 8
Cani PD, et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 2007;56(7):1761–1772. doi: 10.2337/db06-1491.
Dabke K, Hendrick G, Devkota S. The gut microbiome and metabolic syndrome. J Clin Invest. 2019 Oct 1;129(10):4050-4057
Utzschneider KM, Kahn SE. Review: the role of insulin resistance in nonalcoholic fatty liver disease. J Clin Endocrinol Metab 2006;91:4753–4761
Xia S., Zhang X., Zheng S., Khanabdali R., Kalionis B., Wu J., Wan W., Tai X. An Update on Inflamm-Aging: Mechanisms, Prevention, and Treatment. J. Immunol. Res. 2016;2016:8426874.
Chimienti F., Favier A., Seve M. ZnT-8, a pancreatic beta-cell-specific zinc transporter. Biometals. 2005;18:313–317. doi: 10.1007/s10534-005-3687-9.
Grüngreiff K., Franke D., Lössner B., Abicht K., Kleine F.D. Zinc deficiency-A factor in the pathogenesis of hepatic encephalopathy. Z. Gastroenterol. 1991;29:101–106.
Jiang S., Ma X., Li M., Yan S., Zhao H., Pan Y., Wang C., Yao Y., Jin L., Li B. Association between dietary mineral nutrient intake, body mass index, and waist circumference in U.S. Adults using quantile regression analysis NHANES 2007–2014. PeerJ. 2020;8:e9127. doi: 10.7717/peerj.9127.
Kelly O.J., Gilman J.C., Kim Y., Ilich J.Z. Macronutrient Intake and Distribution in the Etiology, Prevention and Treatment of Osteosarcopenic Obesity. Curr. Aging Sci. 2016;10:83–105.
Piuri G, Zocchi M, Della Porta M, Ficara V, Manoni M, Zuccotti GV, Pinotti L, Maier JA, Cazzola R. Magnesium in Obesity, Metabolic Syndrome, and Type 2 Diabetes. Nutrients. 2021 Jan 22;13(2):320.
Moore-Schiltz L., Albert J.M., Singer M.E., Swain J., Nock N.L. Dietary intake of calcium and magnesium and the metabolic syndrome in the National Health and Nutrition Examination (NHANES) 2001–2010 data. Br. J. Nutr. 2015;114:924–935.
Cybulska AM, Schneider-Matyka D, Bosiacki M, Chlubek D, Panczyk M, Grochans E. The Levels of Bioelements in Postmenopausal Women with Metabolic Syndrome. Nutrients. 2022 Oct 2;14(19):4102.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
