საკვანძო სიტყვები
პლანარია
ნეობლასტები
ღეროვანი უჯრედები
პროგენიტორები
მოდულაცია
დიფერენციაცია
Schmidtea mediterranea
როგორ უნდა ციტირება
ანოტაცია
პლანარიებს, ბრტყელი ჭიების სახეობას, გააჩნიათ სხეულის სრული აღდგენის შესანიშნავი უნარი, რაც მათ საშუალებას აძლევს ხელახლა განავითარონ/აღადგინონ ნებისმიერი ანატომიური კომპონენტი ტრავმის ან ქირურგიული მოცილების შემდეგ. პლანარიების მიერ გამოვლენილი შესანიშნავი რეგენერაციული პოტენციალი ემყარება ზრდასრულ ორგანიზმში სომატური პლურიპოტენტური ღეროვანი უჯრედების მნიშვნელოვანი პოპულაციის არსებობას. მათ ნეობლასტებს უწოდებენ. ეს უჯრედები წარმოადგენენ გამორჩეულ სამოდელო სისტემას დიფერენციაციის in vivo პროცესის გამოსაკვლევად. ბოლო რამდენიმე წლის განმავლობაში, FACS-ზე დაფუძნებული ნეობლასტის იზოლაციის, RNAi-ზე დაფუძნებული ფუნქციური ანალიზებისა და მაღალი გამტარუნარიანობის ტექნიკის გამოყენებამ, როგორიცაა single-cell sequencing, ხელი შეუწყო მნიშვნელოვან წინსვლას ნეობლასტის ბიოლოგიის სხვადასხვა ასპექტის გაგებაში. შესაბამისად, პლანარიები წარმოადგენენ ცხოველთა განსაკუთრებულ მოდელს ღეროვანი უჯრედების ბიოლოგიისა და ბიოქიმიის ფაქიზი მექანიზმების გამოსაკვლევად.
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