Keywords
centrosome
replicative senescence
differentiation
cnRNA
How to Cite
Abstract
At the beginning of the 21st century, a new group of RNAs was discovered in the centrosomes of the mollusc Spisula solidissima eggs. These RNAs were named centrosomal RNAs (cnRNAs). Subsequent sequencing of cnRNA11 revealed the presence of a conserved reverse transcriptase domain in its structure. The discovery of this reverse transcriptase domain in cnRNA11 indicates that centrosomes may play a role in information storage and retrieval. Furthermore, the reverse transcriptase enzyme has the potential to impact nuclear DNA, which adds to the significance of cnRNAs. This is why cnRNA is written harmoniously in the centriolar hypothesis of differentiation and replicative senescence.
References
Alliegro MC (2008) RNA Biol 5(4):198–200
Alliegro et al., (2008) Centrosomal RNA correlates with intron-poor nuclear
Alliegro et al., (2009) Methods Cell Biol 94:53–64
Alliegro et al., (2006) Proc Natl Acad Sci USA 103 (24):9034–9038
Azimzadeh et al., (2010) Building the centriole.
Badano et al., (2006) Life without centrioles: cilia in the spotlight.
Bartel et al., (2004) Nat Rev Genet 5:396–400
Basto et al., (2006) Cell 125:1375–1386
Beisson et al., (2003) Basal body/centriole assembly and continuity.
Blower et al., (2007) J Cell Biol 179(7):1365–1373
Bornens et al., (2012) Sci 335 (6067):422–426
Brito et al., (2012) Curr Opin Cell Biol 24 (1):4–13
Chan et al., (2005) The Plant Cell 17:1737–1748
Chapman et al., (2007) Symbiosis 44:23–32
Chichinadze, K. N., & Tkemaladze, D. V. (2008). Centrosomal hypothesis of cellular aging and differentiation. Advances in Gerontology= Uspekhi Gerontologii, 21(3), 367-371. PMID: 19432168
Chichinadze, K. N., & Tkemaladze, D. V. (2008). Centrosomal hypothesis of cellular aging and differentiation. Advances in Gerontology= Uspekhi Gerontologii, 21(3), 367-371. PMID: 19432168
Chichinadze, K., Tkemaladze, D., & Lazarashvili, A. (2012a). New class of RNA and centrosomal hypothesis of cell aging. Advances in Gerontology= Uspekhi Gerontologii, 25(1), 23-28. PMID: 22708440
Chichinadze, K., Tkemaladze, J., & Lazarashvili, A. (2012b). Discovery of centrosomal RNA and centrosomal hypothesis of cellular ageing and differentiation. Nucleosides, Nucleotides and Nucleic Acids, 31(3), 172-183. doi: 10.1080/15257770.2011.648362. PMID: 22356233
Chichinadze, K., Tkemaladze, J., & Lazarashvili, A. (2012c). A new class of RNAs and the centrosomal hypothesis of cell aging. Advances in Gerontology, 2(4), 287-291
Chichinadze, K., Lazarashvili, A., & Tkemaladze, J. (2013). RNA in centrosomes: structure and possible functions. Protoplasma, 250(1), 397-405. doi: 10.1007/s00709-012-0422-6. Epub 2012 Jun 10. PMID: 22684578
Cox et al., (2003) Dev 130:1579–1590
Debec et al., (2010) Cell Mol Life Sci 67 (13):2173–2194
Doxsey et al., (2005) Ann Rev Cell and Dev Biol 21:411–434
Etienne-Manneville S (2004) Traffic 5(7):470–477
Forgács et al., (2005) Cambridge University Press, Cambridge, pp 24–50
Fuentealba et al., (2008) Proc Natl Acad Sci USA 105(22):7732–7737
Gadde et al., (2004) Curr Biol 14:797–805
Gogendeau et al., (2010) Semin Cell Dev Biol 21(2):163–173
Gonzalez C (2008) Curr Opin Cell Biol 20:694–698
Gourlay et al., (2005) Nat Rev Mol Cell Biol 6 (7):583–589
Groisman et al., (2000) Cell
Hachet et al., (2007) Dev Cell 12:531–541
Hatch et al., (2011) Quantitative Biology. Vol. LXXV. pp. 425-431
Heinrich et al., (2009) RNA 15:524–536
Henry et al., (2010) Int Comp Biol 50:720–733
Hiedemann et al., (1977) Cell 10:337–350
Hinchcliffe et al., (2001) Sci 291:1547–1550
Hodges et al., (2010) J Cell Sci 123(Pt 9):1407–1413
Hoyer-Fender S (2010) Semin Cell Dev Biol 21(2):142–147
Jaba, T. (2022). Dasatinib and quercetin: short-term simultaneous administration yields senolytic effect in humans. Issues and Developments in Medicine and Medical Research Vol. 2, 22-31. doi: https://doi.org/10.9734/bpi/idmmr/v2/15155D
Jansen RP (1999) FASEB J 13:455–466
Kim et al., (2009) Mol Cell Biol 10(2):126–139
Kingsley et al., (2007) Evol Dev 9(6):527–539
Kloc et al., (2005) J Cell Sci 118:269–282
Kloc et al., (2001) Int Rev Cytol 203:63–91
Kloc et al., (2002) Cell 108:533–544
Kloc et al., (2004) Dev Biol 266:43–61
Kloc et al., (2008) Exp Cell Res 314 (17):3245–3254
Koledova et al., (2010) Stem Cells Dev 19:1663–1678
Lambert JD (2009) Curr Top Dev Biol 86:107–133
Lambert et al., (2002 Nat 420 (6916):682–686
La Terra et al., (2005) J Cell Biol 168(5):713–722
Lécuyer et al., (2007) Cell 131(1):174–187
Lezhava, T., Monaselidze, J., Jokhadze, T., Kakauridze, N., Khodeli, N., Rogava, M., Tkemaladze J., ... & Gaiozishvili, M. (2011). Gerontology research in Georgia. Biogerontology, 12, 87-91. doi: 10.1007/s10522-010-9283-6. Epub 2010 May 18. PMID: 20480236; PMCID: PMC3063552
Lin H (2008) J Cell Biol 180:257–260
Mahen et al., (2012) Pattern formation in centrosome assembly.
Marlow et al., (2008) Bucky ball functions in Balbiani body assembly and animal-vegetal polarity in the oocyte and follicle cell layer in zebrafish.
Matsaberidze, M., Prangishvili, A., Gasitashvili, Z., Chichinadze, K., & Tkemaladze, J. (2017). To topology of anti-terrorist and anti-criminal technology for educational programs. International Journal of Terrorism & Political Hot Spots, 12.
McManus et al., (2002) Nat Rev Genet 3:737–747
Megraw et al., (2001) Zygotic development without functional mitotic centrosomes.
Mello et al., (1996) The PIE-1 protein and germline specification in C. elegans embryos.
Mitalipov et al., (2009) Totipotency, pluripotency and nuclear reprogramming.
Morrison et al., (2008) Cell 132:598–611
Nigg et al., (2009) Cell 139:663–678
Palazzo et al., (1999) Methods Cell Biol 61:35–56
Pederson T (2006) Nat Cell Biol 8:652–654
Portier et al., (2007) Dev Cell 12:515–529
Prangishvili, A., Gasitashvili, Z., Matsaberidze, M., Chkhartishvili, L., Chichinadze, K., Tkemaladze, J., ... & Azmaiparashvili, Z. (2019). System components of health and innovation for the organization of nano-biomedic ecosystem technological platform. Current Politics and Economics of Russia, Eastern and Central Europe, 34(2/3), 299-305.
Quarmby et al., (2005) J Cell Biol 169(5):707–710
Rabinowitz et al., (2010) Dev 137:4039–4049
Ruzanov et al., (1999) J Cell Sci 112(Pt. 20):3487–3496
Satir et al., (2008) Curr Top Dev Biol 85:63–82
Schatten et al., (2011) Microsc Microanal 17:506–512
Shen et al., (2009) Discov Med 8(43):223–226
Sun et al., (2007) Adv Exp Med Biol 591:58–71
Tekotte et al., (2002) Trends Genet 18(12):636–642
Tkemaladze, J., & Chichinadze, K. (2005a). Potential role of centrioles in determining the morphogenetic status of animal somatic cells. Cell biology international, 29(5), 370-374. doi: 10.1016/j.cellbi.2005.03.003. PMID: 15886028.
Tkemaladze, J. V., & Chichinadze, K. N. (2005b). Centriolar mechanisms of differentiation and replicative aging of higher animal cells. Biochemistry (Moscow), 70, 1288-1303. doi: 10.1007/s10541-005-0261-6. PMID: 16336191
Tkemaladze, J., & Chichinadze, K. (2010). Centriole, differentiation, and senescence. Rejuvenation research, 13(2-3), 339-342. doi: 10.1089/rej.2009.0904. PMID: 20426623
Tkemaladze, J., Tavartkiladze, A., & Chichinadze, K. (2012). Programming and Implementation of Age-Related Changes. In Senescence. IntechOpen. DOI: 10.5772/33420
Tkemaladze, J., & Apkhazava, D. (2019). Dasatinib and quercetin: short-term simultaneous administration improves physical capacity in human. J Biomedical Sci, 8(3), 3.
Tkemaladze, J. (2022). Reduction, proliferation, and differentiation defects of stem cells over time: a consequence of selective accumulation of old centrioles in the stem cells?. Molecular Biology Reports, 50(3), 2751-2761.doi: 10.1007/s11033-022-08203-5. Epub 2022 Dec 30. PMID: 36583780
Tkemaladze, J. (2023). The centriolar hypothesis of differentiation and replicative senescence. Junior Researchers, 1(1). doi: https://doi.org/10.52340/2023.01.01.15
Wadsworth et al., (2004) Trends Cell Biol 14:413–419
Wang et al., (2009) Nat 461(7266):947–955
Weinberg RA (1997) Cell 88(5):573–575
Wheatley DN (1982) The centriole: a central enigma of cell biology.
Wickstead et al., (2011) J Cell Biol 194:513–525
Yamashita et al., (2007) Sci 315:518–521
Yamashita et al., (2010) Cold Spring Harb Perspect Biol 2:a001313
Matsaberidze, M., Prangishvili, A., Gasitashvili, Z., Chichinadze, K., & Tkemaladze, J. (2017). To topology of anti-terrorist and anti-criminal technology for educational programs. International Journal of Terrorism & Political Hot Spots, 12.
Прангишвили, А. И., Гаситашвили, З. А., Мацаберидзе, М. И., Чичинадзе, К. Н., Ткемаладзе, Д. В., & Азмайпарашвили, З. А. (2017a). К топологии антитеррористических и антикриминальных технологии для образовательных программ. In Управление развитием крупномасштабных систем MLSD'2017 (pp. 284-287).
Прангишвили, А. И., Гаситашвили, З. А., Мацаберидзе, М. И., Чхартишвили, Л. С., Чичинадзе, К. Н., Ткемаладзе, Д. В., ... & Азмайпарашвили, З. А. (2017b). Системные составляющие здравоохранения и инноваций для организации европейской нано-биомедицинской екосистемной технологической платформы. In Управление развитием крупномасштабных систем MLSD'2017 (pp. 365-368).
Ткемаладзе Д. , Цомаиа Г ., Жоржолиани И. (2001). Создание искусственных самоадаптирующихся систем на основе Теории Прогноза. Искусственный интеллект. УДК 004.89. Искусственный интеллект. УДК 004.89. https://www.ipai.net.ua/uk/arch-2001-3#
Ткемаладзе, Д. В., & Чичинадзе, К. Н. (2005). Центриолярные механизмы дифференцировки и репликативного старения клеток высших животных. Биохимия, 70(11), 1566-1584.
Чичинадзе, К., Ткемаладзе, Д., & Лазарашвили, А. (2012). Новый класс рнк и центросомная гипотеза старения клеток. Успехи геронтологии, 25(1), 23-28.
Чичинадзе, К. Н., & Ткемаладзе, Д. В. (2008). Центросомная гипотеза клеточного старения и дифференциации. Успехи геронтологии, 21(3), 367-371.