COMPARATIVE ANALYSIS OF THE SUMS OF ALKALOIDS OF SOME SPECIES OF MAHONIA (FAMILY BERBERIDACEAE), INTRODUCED ON THE TERRITORY OF GEORGIA

NIKA TODUA; DAVID CHINCHARADZE; NINA VACHNADZE

doi:10.52340/jecm.2022.03.08

COMPARATIVE ANALYSIS OF THE SUMS OF ALKALOIDS OF SOME SPECIES OF MAHONIA (FAMILY BERBERIDACEAE), INTRODUCED ON THE TERRITORY OF GEORGIA

Авторы

NIKA TODUA
DAVID CHINCHARADZE
NINA VACHNADZE

DOI:

https://doi.org/10.52340/jecm.2022.03.08

Ключевые слова:

Mahonia Nutt, isoqinolin alkaloids, сytotoxic activity

Аннотация

Approaching on comparative phytochemical screening tests of six species of Genus Mahonia Nuttall (Family Berberidaceae), which are introduced on the territory of Georgia, by productivity of biologically active alkaloids our attention deserves: Mahonia aquifolium (Pursh) Nutt., Mahonia bealei (Fort.) Carr; Mahonia japonica (Thunb.) DC.; Mahonia wagneri Join.After studying samples with alkaloids on thin layer chromatography compared with standard solutions, there were identified isoquinoline alkaloids such as: berberine, jatrorrhizine, palmatine, magnoflorine, berbamine and colchicine. The total substance obtained from the vegetative organs of Mahonia aquifolium (Oregon grape) were evaluated for in vitro cytotoxicity against cells of lung carcinoma lines (A-549), colon adenocarcinoma (DLD-1) and normal human fibroblasts (WS-1). As a result, the investigated fractions showed pronounced activity against all cell lines.

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