THE IMPORTANCE OF AGE-RELATED CHANGES IN INTERCALATED DISKS IN THE FUNCTIONING OF CARDIOMYOCYTES
DOI:
https://doi.org/10.52340/jecm.2022.06.023Ключевые слова:
Cardiomyocytes, intercalated disks, ageАннотация
The volume of the extracellular matrix rises along with the age increase. The presence of intercellular junctions and the exchange processes of electrical impulses and ion currents carried out via them is a critical component in the functioning of cardiomyocytes (both primary and secondary). The intercalated discs may engage in compensatory-adaptive responses resulting from age-related involutional processes, as evidenced by an increase in their quantity in the hearts of older rats. The structural integrity of the intercalated discs in young and middle-aged rats may be directly correlated with the highly functional capabilities of the heart muscle. It would be interesting to conduct a more in-depth study of the intercalated discs using immunohistochemical techniques and a comparative analysis of disc histological structure in rats of various ages by extrapolating the findings on the functional capabilities of cardiomyocytes.
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S.V. Savchenko, V.P. Novoselov, A.S. Morozova, R.V. Skrebov, V.A. Gritsinger,
T.A. Ageeva, E.I. Voronina, K.I. Ershov. Histological assessment of intercellular contacts of cardiomyocytes at myocardium ischemia, Messenger of forensic medicine. 2016. 5(3):26-29.
Nepomnyashchy L.M. Morphgenesis of the major all-pathological processes in heart, Novosibirsk: Science, 1991. 349p.
Pieperhoff S, Franke WW. The area composita of adhering junctions connecting heart muscle cells of vertebrates-IV: coalescence and amalgamation of desmosomal and adhaerens junction components - late processes in mammalian heart development. Eur J Cell Biol. 2007; 86:377–391.
Rougier JS, et al. Molecular determinants of channel regulation by the Nedd4/Nedd4-like proteins. Am J Phys Cell Phys. 2005;288:C692–C701.
Saphir O, Karsner HT. An anatomical and experimental study of segmentation of the myocardium and its relation to the intercalated discs. J Med Res. 1924; 44:539–556.
Savchenko S.V. Pathomorphologic researches in medicolegal practice at the present stage/Messenger of forensic medicine. 2015, 4(2):1–24.
Schmidt RE, Dorsey DA, Beaudet LN, et al. Experimental Rat Model: 10.1093/jnen/63.5.450
Shaw RM, Fay AJ, Puthenveedu MA, von Zastrow M, Jan YN, Jan LY. Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctions. Cell. 2007; 128:547-560.
Tandler B, Riva L, Loy F, Conti G, Isola R. High resolution scanning electron microscopy of the intracellular surface of intercalated disks in human heart. Tissue Cell. 2006; 38:417-420.
Tepass U, Truong K, Godt D, Ikura M, Peifer M. Cadherins in embryonic and neural morphogenesis. Nat Rev Mol Cell Biol. 2000; 1:91-100.
Toyofuku T, Yabuki M, Otsu K, Kuzuya T, Hori M, Tada M. Direct association of the gap junction protein connexin-43 with ZO-1 in cardiac myocytes. J Biol Chem. 1998; 273:12725–12731.
Van Breemen VL. Intercalated discs in heart muscle studied with the electron microscope. Anat Rec. 1953; 117:49–63.
Yoshida M, et al. Weaving hypothesis of cardiomyocyte sarcomeres: discovery of periodic broadening and narrowing of intercalated disk during volume-load change. Am J Pathol. 2010; 176:660-678.
Zhou Q, Li L, Zhao B, Guan KL. The hippo pathway in heart development, regeneration, and diseases. Circ Res. 2015; 116:1431-1447.
С.В. Савченко, В.П. Новоселов, А.С. Морозова, Р.В. Скребов, В.А. Грицингер, Т.А. Агеева, Е.И. Воронина, К.И. Ершов. Гистологическая оценка межклеточных контактов кардиомиоцитов //Вестник судебной медицины, 2016, 5(3):26-29.
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