დაბერება და იმუნური სისტემა
ანოტაცია
Natural process of ageing is considerably determined by deterioration the of immune system, called immune senescence, which in turn is affected by genetic and environmental factors and lifestyle. Age related modulations of immune system leads in many cases to the development of immunodeficiences and chronic inflammations, which accounts for vaccine inefficiency, development of autoimmune disorders, oncologic and infection pathologies.
Although certain types of immune cells (NK) could increase in number, overall functional activity of all types of immune cells irreversibly decreases with age. Thymus involution is one of the main changes that develops in immune system with age, which consequently deepens the deterioration of all immune processes. In particular, naïve-T compartment decreases, while memory T cell compartment gets enhanced. Besides, considerable limitation of immune responses are mainly caused by restriction of lymphocyte repertoire (oligoclonality) and appearance of terminal differentiated anergic cells. The extent of immune system deterioration depends whether aging process could be defined as premature, phisiologic or successful.
Discovery of immunobiological markers of longevity holds great clinical importance. Study of mechanisms of immune senescence and the factors that influence it are immensely valuable in unraveling the secrets of successful aging.
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