სიმსივნის მიკროგარემოს დესტრუქცია - პანკრეასის კიბოს მკურნალობის პერსპექტიული სტრატეგია
DOI:
https://doi.org/10.52340/jecm.2022.06.05.11საკვანძო სიტყვები:
Pancreatic ductal adenocarcinoma (PDAC), immunomodulation, ablative therapy (AT), radiofrequency ablation (RFA), irreversible electroporation (IRE), histotripsy, radiotherapy (RT)ანოტაცია
პანკრეასის კიბოს 90%-ზე მეტს პანკრეასის სადინრის ადენოკარცინომა წარმოადგენს. ყოველწლიურად მისი დაახლოებით 500,000 ახალი შემთხვევა და თითქმის ამავე რაოდენობის პაციენტის გარდაცვალება აღირიცხება როგორც ქალებში, ასევე მამაკაცებში. დაავადების ცუდი პროგნოზი სიმსივნის მიკროგარემოს იმუნოსუპრესიული შემადგენლობით შეიძლება აიხსნას. ეს უკანასკნელი სიმსივნის საწინააღმდეგო იმუნური პასუხის ინჰიბირებას უზრუნველყოფს, რაც იწვევს კიბოს წარმოქნის ინიცირებას, მის შეუმჩნეველ, სწრაფ პროგრესირებას და გავრცელებას. სიმსივნური მიკროგარემოს მნიშვნელოვან კომპონენტს მკვრივი დესმოპლასტიკური სტრომა წარმოადგენს. ის იმ ფიზიკურ ბარიერად გვევლინება, რაც პანკრეასის კიბოს მკურნალობის მიმართ რეზისტენტულს ხდის. აბლაციური და სხივური თერაპიის გამოყენებით აღნიშნული მკვრივი და იმუნოსუპრესიული სტრომის დესტრუქციამ, როგორც სიმსივნის საწინააღმდეგო იმუნური პასუხის შესაძლო ჩამრთველმა და გამაძლიერებელმა საშუალებამ, შესაძლოა, დამაიმედებელი შედეგები მოგვცეს. აღნიშნულ სტატიაში ჩვენ მომივიხილავთ სიმსივნის სტრომაზე დამიზნებით აბლაციურ და რადიო თერაპიას, როგორც სიმსივნის საწინააღმდეგო იმუნიტეტის პოტენციურ გამააქტიურებლებს.
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