TRANSIENT HYPERTROPHIC CARDIOMYOPATHY IN AN INFANT OF A DIABETIC MOTHER: CLINICAL CASE
DOI:
https://doi.org/10.52340/jecm.2026.03.06Keywords:
hypertrophic cardiomyopathy, infant, diabetic mother, echocardiographyAbstract
Introduction: Hypertrophic cardiomyopathy (HCM) is a common inherited cardiomyopathy characterized by left ventricular hypertrophy, with an annual pediatric incidence of 0.3–0.5 per 100,000. A distinct subset is transient HCM in infants of diabetic mothers (IDMs), seen echocardiographically in 13–44% of such infants, symptomatic in up to 12.1%.
Case: A male neonate born at 36 6/7 weeks to a mother with insulin-dependent type 2 diabetes and pre-eclampsia developed respiratory distress at birth. Echocardiography showed biventricular hypertrophy with predominant septal thickening (IVSD 0.92 cm), preserved EF (75%), and no outflow obstruction. He was discharged stable on day 11. At one month, repeat echocardiography showed marked regression (IVSD 0.4 cm, EF 81%) without pharmacologic therapy.
Conclusion: Transient HCM in IDMs is a self-limited, hyperinsulinemia-driven condition. Early echocardiographic screening and serial monitoring are essential to distinguish it from genetic HCM and guide management.
Downloads
References
1. Martin S maron. Hypertrophic cardiomyopathy in children: Clinical manifestations and diagnosis. UpToDate, 2025. https://www.uptodate.com/contents/hypertrophic-cardiomyopathy-clinical-manifestations-diagnosis-and-evaluation
2. Bordin G, et al. Hypertrophic cardiomyopathy in infant newborns of diabetic mother. Italian Journal of Pediatrics, 2021;47:198.
3. Parikh P, Hypertrophic cardiomyopathy - neonatal. Case study, Radiopaedia.org (Accessed on 30 Aug 2026) https://doi.org/10.53347/rID-63314.
4. Samir A, Nassar C, Idriss GM, Abou-Elyazid H, Alzahrani SA. Echocardiographic Findings in Infants of Diabetic Mothers. Cureus. 2025 Sep 16;17(9):e92493. doi: 10.7759/cureus.92493. PMID: 41111825; PMCID: PMC12531403.
5. Paulo Zielinsky, Antonio Luiz Piccoli, Myocardial hypertrophy and dysfunction in maternal diabetes, Early Human Development, Volume 88, Issue 5, 2012, Pages 273-278, ISSN 0378-3782, https://doi.org/10.1016/j.earlhumdev.2012.02.006.
6. Animaw lingerew. Case presentation Title: Reversible Neonatal Hypertrophic Cardiomyopathy in an Infant of a Diabetic Mother: A Case Report and Review of Clinical Principles. NeoCardio Lab. Case of the Month: IDM Cardiac Hypertrophy, August 2025. https://www.neocardiolab.com/case-of-the-month-cas-du-mois/case-august-2025-idm-cardiac-hypertrophy
Downloads
Published
How to Cite
Issue
Section
